β-Lapachone
Chemical Name: 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Purity: ≥98%
Biological Activity
DNA topoisomerase I inhibitor. Exhibits a different inhibitory mechanism to camptothecin (Cat. No. 1100). Induces apoptosis in a variety of cell lines, including prostate cancer and promyelocytic leukemia cells; blocks the cell cycle in G0/G1. Also has effects on DNA topoisomerase II, NF-κB, AP-1, and JNK.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Induction of apoptosis in MCF-7:WS8 breast cancer cells by β-Lapachone.
Wuerzberger et al.
Cancer Res., 1998;58:1876 -
Beta-Lapachone, a novel topoisomerase I inhibitor with a mode of action different from camptothecin.
Li et al.
J.Biol.Chem., 1993;268:22463 -
Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β lapachone.
Manna et al.
Biochem.Pharmacol., 1999;57:763 -
Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway
Shiah et al.
Cancer Res., 1999;59:391
Product Datasheets
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Citation for β-Lapachone
The citations listed below are publications that use Tocris products. Selected citations for β-Lapachone include:
1 Citation: Showing 1 - 1
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Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1.
Authors: Joshi Et al.
Cell Death Differ 2016;23:216
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