Chemical Name: 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Biological Activityβ-Lapachone is a DNA topoisomerase I inhibitor. Exhibits a different inhibitory mechanism to camptothecin (Cat. No. 1100). Induces apoptosis in a variety of cell lines, including prostate cancer and promyelocytic leukemia cells; blocks the cell cycle in G0/G1. Also has effects on DNA topoisomerase II, NF-κB, AP-1, and JNK.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of apoptosis in MCF-7:WS8 breast cancer cells by β-Lapachone.
Wuerzberger et al.
Cancer Res., 1998;58:1876
Beta-Lapachone, a novel topoisomerase I inhibitor with a mode of action different from camptothecin.
Li et al.
Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β lapachone.
Manna et al.
Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway
Shiah et al.
Cancer Res., 1999;59:391
Citation for β-Lapachone
The citations listed below are publications that use Tocris products. Selected citations for β-Lapachone include:
1 Citation: Showing 1 - 1
Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1.
Authors: Joshi Et al.
Cell Death Differ 2016;23:216
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