Bioactivity of Blood Coagulation Proteins

Human XL Cytokine Discovery Luminex

Get Superior Bioactivity with R&D Systems® Coagulation Proteins

R&D Systems is the world’s premiere source of recombinant proteins. Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

Our recombinant proteins in the coagulation cascade are tested for activity in biologically relevant assays. If you need reagents that exhibit native function, you can rely on ours to give you results that make sense for coagulation biology. Every production lot of recombinant protein must meet our Quality Control specifications before we offer it for sale. That means you can count on each of these proteins to give you reliable and trustworthy results.

  • Lot-to-lot consistency
  • Biological activity
  • Endotoxin level and microbial bioburden test
  • Protein sequence accuracy
  • Formulation

Select examples of bioactivity data for R&D Systems® Coagulation Proteins

We offer bioactive proteins for each of these proteins involved in coagulation. We also offer an extensive selection of antibodies, immunoassays, small molecule regulators for these molecules. Click on the links to browse our catalog.

Coagulation Factors

Coagulation Factor II/Thrombin human
Coagulation Factor III/Tissue Factor human/mouse
Coagulation Factor VII human/mouse
Coagulation Factor X human/mouse
Coagulation Factor XI human/mouse
Coagulation Factor XIV/Protein C human/mouse
Coagulation Factor IX human

Coagulation Cascade Proteases

ADAMTS13 human
Plasma Kallikrein/KLKB1 human/mouse
t-Plasminogen Activator/tPA human
u-Plasminogen Activator (uPA)/Urokinase human

Coagulation Cascade Protease Inhibitors

alpha 2-Macroglobulin human
alpha 2-Macroglobulin-like 1/A2ML1 human
Kininogen human/mouse
Serpin A1/alpha 1-Antitrypsin human/mouse
Serpin A1c/alpha 1-Antitrypsin mouse
Serpin A5/Protein C Inhibitor human
Serpin A10/ZPI human
Serpin A1a mouse
Serpin B2 human
Serpin C1/Antithrombin-III human
Serpin D1/Heparin Cofactor II human/mouse
Serpin E1/PAI-1 human
TFPI human/mouse
TFPI-2 human

Plasmin/Plasminogen and Kallikrein/Kinin Systems

Angiostatin human
Kallikrein 1 human/mouse
Kallikrein 3/PSA human
Kallikrein 4/Prostase/EMSP1 human
Kallikrein 5 human/mouse
Kallikrein 7 human/mouse
Kallikrein 13 human
Kallikrein 14 human
Plasma Kallikrein/KLKB1 human/mouse
Kininogen human/mouse
Kininostatin human
PGK1 human
Serpin A4/Kallistatin human
Serpin B2 human
Serpin E1/PAI-1 human
Serpin F2/alpha 2-Antiplasmin human/mouse
t-Plasminogen Activator/tPA human
u-Plasminogen Activator (uPA)/Urokinase human
uPAR human/mouse

Other Coagulation Cascade Molecules

Angiostatin human
Annexin A6 human
Apolipoprotein H/ApoH human/mouse
CD42b/GPIb alpha human/mouse
Collagen II human
CXCL4/PF4 human/mouse/rat
ENPP-4 mouse
EPCR human/mouse
FGL2 mouse
G6b human/mouse
Glycoprotein V/CD42d human/mouse
GPVI human/mouse
Heparanase/HPSE human
Protein S/PROS1 human
Thrombomodulin/BDCA-3 human/mouse
uPAR human/mouse
VISTA/B7-H5/PD-1H human/mouse/cynomolgus
vWF-A2 human

Thumbnails of activity data

Click on the graphs for a larger image

Kallikrein 5
Recombinant Human Kallikrein 5 (Catalog #1108-SE) cleaves the fluorogenic peptide substrate Boc-VPR-AMC (Catalog #ES011). The specific activity is >200 pmol/min/μg, as measured under the described conditions.
Kallikrein 5
 
 
Serpin A1/alpha 1-Antitrypsin
Recombinant Human Serpin A1/alpha-1-Antitrypsin (Catalog #1268-PI) inhibits trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The IC50 value is approximately <5.0 nM, as measured under the described conditions.
Serpin A1/alpha 1-Antitrypsin
 
 
u-Plasminogen Activator (uPA)/Urokinase
Recombinant Human u-Plasminogen Activator/Urokinase (Catalog #1310-SE) cleaves a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >2,000 pmol/min/μg, as measured under the described conditions.
u-Plasminogen Activator (uPA)/Urokinase
 
 
Kallikrein 3/PSA
Recombinant Human Kallikrein 3/PSA (Catalog #1344-SE) cleaves the colorimetric peptide substrate, Succinyl-Arg-Pro-Tyr-p-Nitroanilide (Suc-RPY-pNA). The specific activity is >70 pmol/min/μg, as measured under the described conditions.
Kallikrein 3/PSA
 
 
Serpin E1/PAI-1
Recombinant Human Serpin E1/PAI-1 (Catalog #1786-PI) inhibits uPA cleavage of a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The IC50 value is <13 nM, as measured under the described conditions.
Serpin E1/PAI-1
 
 
Kallikrein 7
Recombinant Human Kallikrein 7 (Catalog #2624-SE) cleaves the fluorogenic peptide substrate Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The specific activity is >150 pmol/min/µg, as measured under the described conditions.
Kallikrein 7
 
 
Kallikrein 14
Recombinant Human Kallikrein 14 (Catalog #2626-SE) cleaves the fluorogenic peptide substrate Boc-VPR-AMC (Catalog #ES011). The specific activity is >3,000 pmol/min/μg, as measured under the described conditions.
Kallikrein 14
 
 
TFPI
Recombinant Human TFPI (Catalog #2974-PI) inhibits trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The IC50 value is <0.75 nM, as measured under the described conditions.
TFPI
 
 
t-Plasminogen Activator/tPA
Recombinant Human t-Plasminogen Activator/tPA (Catalog #7449-SE) cleaves a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >190 pmol/min/μg, as measured under the described conditions.
t-Plasminogen Activator/tPA