Purified Proteins for Immunotherapy Research and Clinical Manufacturing
Find Your Immunotherapy Proteins
The immune system plays a key role in the recognition and destruction of cancerous cells. Utilizing and enhancing these properties lies at the heart of immunotherapy. Immune checkpoint therapies that target immuno-suppressive proteins such as PD-1, PD-L1 and CTLA4 have led to transformative new treatments for cancer. Purified versions of the proteins are critical for the development of antibodies, drug screening, and quality control assay development. In addition, novel proteins will help define the next generation of Immunotherapy targets.
Good Manufacturing Practices (GMP)-grade Proteins
High-quality raw materials and ancillary reagents are needed for ex vivo cell manufacturing processes. View our GMP protein portfolio.
Biotinylated Proteins: Avi-tag and Amine Biotinylation
R&D Systems offers an expanding line of Avi-tag and amine-labeled biotinylated proteins. QC tested for equivalent bioactivity and lot-to-lot consistency.
Immune Checkpoint Proteins and Enzymes
Popular Immune Checkpoint proteins
| PD-1 | PD-L1 |
| CTLA-4 | CD28 |
| TIGIT | CD155/PVR |
| SIRP alpha | CD47 |
| 4-1BB | 4-1BB Ligand |
| B7-1 | B7-2 |
| LAG-3 | Galectin-9 |
| CD40 | CD40 Ligand |
| ICOS | VISTA/B7-H5 |
Next Generation Immune Checkpoint Proteins
| Siglecs | VSTMs |
| Butyrophilins | VSIGs |
| CEACAMs | LILRA/B |
NEW! Fluorescent-labeled Proteins
Simplify your CAR validation workflow. Bioactive CD19, BCMA, and more conjugated to fluorescent Atto dyes ideal for evaluating CAR expression. Our Fluorescent-labeled proteins are tested using stringent QC standards to ensure consistent labeling while maintaining binding activity and come in a ready to use liquid format eliminating the need for reconstitution. Learn more.
Cynomolgus and Rhesus Proteins
R&D Systems has over 80 cynomolgus and rhesus proteins specifically targeting the Immunotherapy research field.
Custom Protein Development
Utilize our expertise in protein expression, cell culture, protein purification, conjugation, and formulation to create an optimized protein of your choice.
Featured Content
SEC-MALS for Protein Characterization
Discover how Bio-Techne prioritizes your success with cutting-edge techniques like SEC-MALS for protein characterization.
Application Note: Evaluating CAR Expression on CAR-T Cells Using Fluorokines™
Learn about the advantages of using fluorescent-labeled proteins to directly stain and detect CAR+ cells by flow cytometry.
Webinar - How Cancer Circumvents the Immune System
Topics covered: Understanding immune inhibitory mechanisms in cancer, and Modeling T-cell dysfunction in colon cancer.
Webinar - The CAR ToolKit: Progress and Challenges in CAR-T/NK Cell R&D and Manufacture
Learn about the current challenges, latest progress, and innovation facing CAR-T and CAR-NK cell development.
Immune Checkpoint Targets eBook
Learn about the latest research on current and emerging immune checkpoint targets for cancer immunotherapy
Avi-tag Biotinylated Proteins Application Note
See how our Avi-tag biotinylated proteins can be used to determine protein interaction kinetics and affinity with SPR.