c-jun [p Ser63] Antibody (S07-3G7)

Name: c-jun [p Ser63] Antibody (S07-3G7)
Brand: Novus Biologicals
SKU: NBP3-20024
Price: 569 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-20024

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-3G7 expressed in HEK293

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Product Specifications

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser63 of human c-jun (Uniprot # P05412)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for c-jun [p Ser63] Antibody (S07-3G7)

Western Blot: c-jun [p Ser63] Antibody (S07-3G7) [NBP3-20024] - Western blot detection of Phospho-c-Jun (Ser63) in K562, C6, 3T3 cell lysates using NBP3-20024 (1:1000 diluted). Predicted band size: 36kDa. Observed band size: 43kDa.

Immunohistochemistry-Paraffin: c-jun [p Ser63] Antibody (S07-3G7) [NBP3-20024] - Immunohistochemistry of c-jun (phospho S63) in paraffin-embedded Human breast cancer tissue using NBP3-20024 at dilution 1/20

Applications for c-jun [p Ser63] Antibody (S07-3G7)

Application

Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: c-Jun

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Long Name

Cellular Repressor of E1A-stimulated Genes/Transcription Factor AP-1

Alternate Names

cJun, JUN

Gene Symbol

JUN

Additional c-Jun Products

Product Documents for c-jun [p Ser63] Antibody (S07-3G7)

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Product Specific Notices for c-jun [p Ser63] Antibody (S07-3G7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.