Canine CD8 alpha Alexa Fluor™ Plus 680‑conjugated Antibody

Name: Canine CD8 alpha Alexa Fluor™ Plus 680‑conjugated Antibody
Brand: R&D Systems
SKU: FAB6709AFP680
Price: 569 USD
Availability: InStock

R&D Systems | Catalog # FAB6709AFP680

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas
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Key Product Details

Species Reactivity

Canine

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG₁ Clone # 569126

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Product Specifications

Specificity

Detects canine CD8 alpha in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant CD8 from human, mouse, cotton rat, cat, or guinea pig is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Applications for Canine CD8 alpha Alexa Fluor™ Plus 680‑conjugated Antibody

Application

Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CD8

CD8 is a dimeric complex made up of two Ig superfamily members. The CD8 alpha chain is a 34 kDa type I transmembrane glycoprotein that is disulfide-linked either to itself forming CD8 alpha alpha, or to an unrelated 30‑35 kDa CD8 beta chain, forming CD8 alpha beta. CD8 alpha contains one V-type Ig-like domain in its extracellular region (ECD) that binds to class I MHC molecules. CD8 alpha beta is a TCR coreceptor, while CD8 alpha alpha promotes T cell survival and differentation. Within the ECD, canine CD8 alpha shares 63%, 45%, 43%, 68%, and 54% amino acid identity with human, mouse, rat, feline, and porcine CD8 alpha, respectively.

Alternate Names

CD8, CD8A

Entrez Gene IDs

925 (Human); 12525 (Mouse); 24930 (Rat); 102124337 (Cynomolgus Monkey); 493799 (Feline)

Gene Symbol

CD8A

UniProt

P33706

Additional CD8 Products

Product Documents for Canine CD8 alpha Alexa Fluor™ Plus 680‑conjugated Antibody

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Certificate of Analysis

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Product Specific Notices for Canine CD8 alpha Alexa Fluor™ Plus 680‑conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only