Cannabinoid R1/CB1/CNR1 Antibody

Novus Biologicals | Catalog # NB300-552

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Cannabinoid R1/CB1/CNR1 Primary Antibodies »

Product Specifications

Immunogen

A fusion protein containing the first 99 amino acid residues from human CB1.

Localization

Integral membrane protein

Specificity

Detects CB1 from human and rat tissues as well as transfected rat CB1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cannabinoid R1/CB1/CNR1 Antibody

Immunocytochemistry/ Immunofluorescence: Cannabinoid R1/CB1/CNR1 Antibody [NB300-552]

Immunocytochemistry/ Immunofluorescence: Cannabinoid R1/CB1/CNR1 Antibody [NB300-552]

Immunocytochemistry/Immunofluorescence: Cannabinoid R1/CB1/CNR1 Antibody [NB300-552] - Immunlocalization of rat CB1 transfected into AtT20 cells.

Applications for Cannabinoid R1/CB1/CNR1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:1000

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

1:250
Application Notes
WB: Detects an approx. 60 kDa protein representing CB1 from rat brain homogenate. ICC: Staining of CB1 in AtT20 cells transfected with the rat CB1 gene yields a pattern consistent with plasma membrane staining.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA and 30% glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cannabinoid R1/CB1/CNR1

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

Long Name

Cannabinoid Receptor 1

Alternate Names

CANN6, CannabinoidR1, CB-R, CB1, CB1A, CB1K5, CB1R, CNR1, SKR6R

Entrez Gene IDs

1268 (Human); 25248 (Rat)

Gene Symbol

CNR1

Additional Cannabinoid R1/CB1/CNR1 Products

Product Documents for Cannabinoid R1/CB1/CNR1 Antibody

Certificate of Analysis

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Product Specific Notices for Cannabinoid R1/CB1/CNR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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