Chemical Name: (2E)-2-Butenoic acid
Biological ActivityInduces histone modifications in chemically induced pluripotent stem cells (CiPSCs). Activates gene expression, facilitates telomere maintenance and increases telomere length, and enhances reprogramming of MEFs to iPSCs using a small molecule cocktail including valproic acid (Cat. No. 2815), CHIR 99021 (Cat. No. 4423), tranylcypromine (Cat. No. 3852), forskolin (Cat. No. 1099), AM 580 (Cat. No. 0760), EPZ 004777 (Cat. No. 5567), SGC 0946 (Cat. No. 4541) and PD 0325901 (Cat. No. 4192).
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dynamics of telomere rejuvenation during chemical induction to pluripotent stem cells.
Fu et al.
Stem Cell Reports, 2018;11:70
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