Dermcidin Antibody (G-81)

Novus Biologicals | Catalog # NBP1-49620

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunoassay, Immunocytochemistry/ Immunofluorescence

Cited:

Immunocytochemistry/ Immunofluorescence, IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Clone # G-81
View all Dermcidin Primary Antibodies »

Product Specifications

Immunogen

Fractioned sweat peptides in complete Freunds adjuvant

Specificity

The monoclonal antibody G-81 was produced against a sweat-specific antigen. It reacts to sweat but not to other body fluids (e.g. serum, saliva, semen, milk, urine and tears) in ELISA. The N-terminal amino acid sequence (18 amino acids residues) is identical to a part of human cachexia-associated protein and of a survival-promoting peptide for neuronal cells. Besides this, the sequence is identical to the C-terminal peptide (amino acids 62-79) of DCD. The monoclonal antibody G81 can be used as a specific marker for eccrine glands in the human skin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgM

Applications for Dermcidin Antibody (G-81)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10-1:500

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000
Application Notes
For immunohistology and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Immunocytochemistry/Immunofluorescence was reported in scientific literature.

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant

Preservative

0.02% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Dermcidin

The monoclonal antibody G-81 recognizes a fragment of human dermcidin (DCD). The antibiotic peptide dermcidin (110 amino acids) is specifically and constitutively expressed in the sweat glands. DCD is localized to the dark mucous cells of normal eccrine sweat glands. DCD is normally expressed in eccrine sweat glands and is expressed in cutaneous mixed tumours. DCD-immunopositive cells are expressed in the inner cells of the tubular and ductal structures. The monoclonal antibody G-81 is useful as a immunohistochemical tool to find the tumour cells that differentiate towards eccrine secretory cells in cutaneous mixed tumours. Furthermore, the antibody can be used for the detection of biochemical and histochemical changes of the sweat gland in the healing process of wound.

Alternate Names

AIDDdiffusible survival/evasion peptide, DCD-1, dermcidin, DSEPpreproteolysin, HCAP, MGC71930, PIF, Preproteolysin, proteolysis inducing factor, survival promoting peptide

Entrez Gene IDs

117159 (Human)

Gene Symbol

DCD

UniProt

P81605 (Human)

Additional Dermcidin Products

Product Documents for Dermcidin Antibody (G-81)

Certificate of Analysis

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Product Specific Notices for Dermcidin Antibody (G-81)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Dermcidin Antibody (G-81)

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Protocols

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