Potent inhibitor of AMP-activated protein kinase (AMPK) (K
= 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC
, PKA and JAK3. Inhibits AMPK activation induced by
(Cat. No. 2840) and
(Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs)
. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
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All Tocris products are intended for laboratory research use only.
The citations listed below are publications that use Tocris products.
Selected citations for Dorsomorphin dihydrochloride include:
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Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nat Commun 2018;9(1):475
Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
Authors: Dai Et al.
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Authors: Kapeli Et al.
Nature Communications 2016;7:12143
Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
Physiological Reports 2016;4:e13069
Effects of thrombin on insulin signalling and glucose uptake in cultured human myotubes.
Authors: Al-Bayati Et al.
J Diabetes Complications 2016;30:1209
Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy.
Authors: Puente Et al.
J Biol Chem 2016;291:6026
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
Authors: Nott Et al.
Nat Neurosci 2016;19:1497
Adenosine monophosphate-activated protein kinase activation mediates the leptin-induced attenuation of cognitive impairment in a streptozotocin-induced rat model.
Authors: Zhu Et al.
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Authors: Rempel Et al.
Arch Toxicol 2015;89:1599
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Authors: Palm Et al.
Int J Mol Sci 2015;5:16321
Transcription factor binding dynamics during human ES cell differentiation.
Authors: Tsankov Et al.
Biomed Res Int 2015;518:344
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Authors: Liao Et al.
Exp Ther Med 2015;47:469
Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
Authors: Sposito Et al.
Sci Rep 2015;24:5260
Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury.
Authors: Matsuda Et al.
BMC Neurosci 2015;2015:635041
Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.
Authors: Khan Et al.
J Pharmacol Exp Ther 2015;16:42
Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan.
Authors: Chen Et al.
Exp Neurol 2015;16:2497
A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.
Authors: Ueki Et al.
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Authors: Obba Et al.
Nat Protoc 2015;11:1114
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang Et al.
Nat Genet 2015;10:413
Bmp suppression in mangrove killifish embryos causes a split in the body axis.
Authors: Mourabit Et al.
PLoS One 2014;9:e84786
BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
Authors: Graham Et al.
Nat Neurosci 2014;5:5667
Co-operative Bmp- and Fgf-signaling inputs convert skin wound healing to limb formation in urodele amphibians.
Authors: Makanae Et al.
Dev Biol 2014;396:57
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Authors: Huang Et al.
Nat Biotechnol 2014;32:84
Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development.
Authors: Holtzhausen Et al.
FASEB J 2014;28:1248
Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
Authors: Virtanen Et al.
Mol Cancer Res 2014;12:1863
Bmp and Shh signaling mediate the expression of satb2 in the pharyngeal arches.
Authors: Sheehan-Rooney Et al.
PLoS One 2013;8:e59533
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Authors: Reinhardt Et al.
PLoS One 2013;8:e59252
EGF stimulates Müller glial proliferation via a BMP-dependent mechanism.
Authors: Ueki and Reh
Moderate excess of pyruvate augments osteoclastogenesis.
Authors: Fong Et al.
Biol Open 2013;2:387
Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
Authors: Kim Et al.
J Biol Chem 2013;288:22693
Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
Authors: Taub Et al.
Stem Cells Dev 2013;27:342
Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
Authors: Pol Et al.
Lab Chip 2013;247:694
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Authors: Brafman Et al.
Cell Metab 2013;20:369
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
Authors: Li Et al.
Nat Commun 2013;13:1969
Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.
Authors: Knelson Et al.
J Clin Invest 2013;123:4786
Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage.
Authors: Hou Et al.
J Cereb Blood Flow Metab 2012;32:2201
Engineering artificial signaling centers to polarize embryoid body differentiation.
Authors: Petersen Et al.
Br J Pharmacol 2012;21:647
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
Authors: Shi Et al.
FASEB J 2012;15:477
Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons.
Authors: Dhillon and Belsham
Int J Obes (Lond) 2011;35:198
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Hum Mol Genet 2011;339:886
Orexin is required for brown adipose tissue development, differentiation, and function.
Authors: Sellayah Et al.
Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo.
Authors: Lou Et al.
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30 minute pre-incubation
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