Dorsomorphin dihydrochloride

Tocris Bioscience | Catalog # 3093

Potent AMPK inhibitor; also BMP type I receptor inhibitor
Tocris Bioscience

Key Product Details

Description

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternative Names

Compound C,BML-275
View all AMPK Inhibitors »

Product Description

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. The compound can also be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. Also used in a protocol to generate brain organoids from human iPSCs.

Product Specifications for Dorsomorphin dihydrochloride

Molecular Weight

472.41

Formula

C24H25N5O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride

CAS Number

1219168-18-9

PubChem ID

49761481

InChI Key

RJDVIJJQKMGPMV-UHFFFAOYSA-N

SMILES

C(C=N2)(C4=CC=C(OCCN5CCCCC5)C=C4)=CN1C2=C(C3=CC=NC=C3)C=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.24 100
DMSO 9.45 20 with gentle warming

Preparing Stock Solutions for Dorsomorphin dihydrochloride

The following data is based on the product molecular weight 472.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Documents for Dorsomorphin dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dorsomorphin dihydrochloride

For research use only

Related Research Areas

Autophagy
Intracellular Kinases
Obesity

Citations for Dorsomorphin dihydrochloride

Customer Reviews for Dorsomorphin dihydrochloride (3)

4.7 out of 5
3 Customer Ratings
5 Stars
67%
4 Stars
33%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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  • We got expected effect on cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary pancreatic ductal epithelial cells
    Verified Customer | Posted 04/03/2020
    5 μ Dorsomorphin
    Dorsomorphin dihydrochloride 3093
  • Neural Induction Conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: H9
    Verified Customer | Posted 03/22/2020
    2 μM dorsomorphin
    Dorsomorphin dihydrochloride 3093
  • Inhibition of AMP kinase in acute brain slices
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: acute brain slice
    Verified Customer | Posted 01/10/2018
    30 minute pre-incubation
    On acute brain slices, to investigate the role of AMP kinase. The effect was minimal but close to what was expected.

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