Potent inhibitor of AMP-activated protein kinase (AMPK) (Ki
= 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ
, PKA and JAK3. Inhibits AMPK activation induced by AICAR
(Cat. No. 2840) and metformin
(Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro
. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Role of AMP-activated protein kinase in mechanism of metformin action.
Zhou et al.
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
Yu et al.
Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
Vucicevic et al.
Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.
Hao et al.
PLoS ONE, 2008;3:2904
A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells.
Diekmann et al.
Stem Cells Dev., 2015;24:190
The citations listed below are publications that use Tocris products. Selected citations for Dorsomorphin dihydrochloride include:
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