Dorsomorphin dihydrochloride

  ( 43 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3093
Alternate Names:Compound C, BML-275
Chemical Name:6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Product Details
Citations (43)
Supplemental Products
Biological Activity
Potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and metformin (Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Dorsomorphin dihydrochloride include:

43 Citations: Showing 1 - 10
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  1. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  2. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
    Authors: Dai Et al.
    Autophagy  2017;13:1435
  3. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  4. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  5. Effects of thrombin on insulin signalling and glucose uptake in cultured human myotubes.
    Authors: Al-Bayati Et al.
    J Diabetes Complications  2016;30:1209
  6. Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy.
    Authors: Puente Et al.
    J Biol Chem  2016;291:6026
  7. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  8. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  9. Adenosine monophosphate-activated protein kinase activation mediates the leptin-induced attenuation of cognitive impairment in a streptozotocin-induced rat model.
    Authors: Zhu Et al.
    Nature  2015;9:1998
  10. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  11. Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
    Authors: Palm Et al.
    Int J Mol Sci  2015;5:16321
  12. Transcription factor binding dynamics during human ES cell differentiation.
    Authors: Tsankov Et al.
    Biomed Res Int  2015;518:344
  13. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
    Authors: Liao Et al.
    Exp Ther Med  2015;47:469
  14. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Sci Rep  2015;24:5260
  15. Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury.
    Authors: Matsuda Et al.
    BMC Neurosci  2015;2015:635041
  16. Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.
    Authors: Khan Et al.
    J Pharmacol Exp Ther  2015;16:42
  17. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan.
    Authors: Chen Et al.
    Exp Neurol  2015;16:2497
  18. A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.
    Authors: Ueki Et al.
    Development  2015;142:533
  19. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Nat Protoc  2015;11:1114
  20. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Genet  2015;10:413
  21. Bmp suppression in mangrove killifish embryos causes a split in the body axis.
    Authors: Mourabit Et al.
    PLoS One  2014;9:e84786
  22. BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
    Authors: Graham Et al.
    Nat Neurosci  2014;5:5667
  23. Co-operative Bmp- and Fgf-signaling inputs convert skin wound healing to limb formation in urodele amphibians.
    Authors: Makanae Et al.
    Dev Biol  2014;396:57
  24. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  25. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development.
    Authors: Holtzhausen Et al.
    FASEB J  2014;28:1248
  26. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
    Authors: Virtanen Et al.
    Mol Cancer Res  2014;12:1863
  27. Bmp and Shh signaling mediate the expression of satb2 in the pharyngeal arches.
    Authors: Sheehan-Rooney Et al.
    PLoS One  2013;8:e59533
  28. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt Et al.
    PLoS One  2013;8:e59252
  29. EGF stimulates Müller glial proliferation via a BMP-dependent mechanism.
    Authors: Ueki and Reh
    Glia  2013;61:778
  30. Moderate excess of pyruvate augments osteoclastogenesis.
    Authors: Fong Et al.
    Biol Open  2013;2:387
  31. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem  2013;288:22693
  32. Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
    Authors: Taub Et al.
    Stem Cells Dev  2013;27:342
  33. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Lab Chip  2013;247:694
  34. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman Et al.
    Cell Metab  2013;20:369
  35. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.
    Authors: Li Et al.
    Nat Commun  2013;13:1969
  36. Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.
    Authors: Knelson Et al.
    J Clin Invest  2013;123:4786
  37. Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage.
    Authors: Hou Et al.
    J Cereb Blood Flow Metab  2012;32:2201
  38. Engineering artificial signaling centers to polarize embryoid body differentiation.
    Authors: Petersen Et al.
    Br J Pharmacol  2012;21:647
  39. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    Authors: Shi Et al.
    FASEB J  2012;15:477
  40. Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons.
    Authors: Dhillon and Belsham
    Int J Obes (Lond)  2011;35:198
  41. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Hum Mol Genet  2011;339:886
  42. Orexin is required for brown adipose tissue development, differentiation, and function.
    Authors: Sellayah Et al.
    Autophagy  2011;14:478
  43. Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo.
    Authors: Lou Et al.
    Development  2011;138:3113
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  Mouse Anonymous 01/10/2018


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Other Experimental Details 30 minute pre-incubation

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