Catalog Number: 2991
Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline
Biological Activity
Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.
Technical Data
  • M.Wt:
    499.3
  • Formula:
    C15H23N3O12P2
  • Solubility:
    Soluble to 2 mM in water with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    927866-58-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence from the Medical Research Council.
Background References
  1. Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region.
    Wieboldt et al.
    Biochemistry, 1994;33:1526
  2. Presynaptic miniature GABAergic currents in developing interneurons.
    Trigo
    Neuron, 2010;66:235
  3. Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ.
    Trigo et al.
    J.Neurosci.Meths., 2009;181:159
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:

1 Citations: Showing 1 - 1

  1. Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination.
    Authors: Nunez-Parra Et al.
    PLoS One 2013;110:14777

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