ELA-32 (human)

Catalog #: 6291 Datasheet / COA / SDS

Discontinued Product

6291 has been discontinued.
View all Apelin Receptor Agonists products.
ELA-32 (human)
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Description: Potent and high affinity apelin agonist; stimulates angiogenesis
Alternative Names: APJ early endogenous ligand, Apela, Elabela, Toddler
Product Details

Biological Activity

ELA-32 (human) is a potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. Also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. Stimulates angiogenesis in HUVEC cells. Relaxes mouse aortic vessels. Functions as an anorexigenic hormone through activation of the AVP and CRH neurons in the PVN.

Negative control (Cat.No. 6292) also available.

Technical Data


(Modifications: Disulfide bridge: 17-22)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Additional Information

Licensing Caveats:
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.
Other Product-Specific Information:

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