Biological Activity Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Soluble to 10 mM in DMSO with gentle warming and to 20 mM in ethanol
Store at +4°C
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All Tocris products are intended for laboratory research use only.
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