Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
Biological ActivityGanaxolone is a potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor.
Carter et al.
Effect of ganaxolone in a rodent model of cerebral hematoma.
Lyden et al.
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Ungard et al.
Citation for Ganaxolone
The citations listed below are publications that use Tocris products. Selected citations for Ganaxolone include:
1 Citation: Showing 1 - 1
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Authors: Asiedu Et al.
J Pain 2012;13:546
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