Potent positive allosteric modulator of GABAA
receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA
values are 94, 122 and 213 nM for α
receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
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Effect of ganaxolone in a rodent model of cerebral hematoma.
Lyden et al.
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Ungard et al.
Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor.
Carter et al.