Catalog Number: 2531
Alternate Names: CCD 1042
Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
Biological Activity
Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 20 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of ganaxolone in a rodent model of cerebral hematoma.
    Lyden et al.
    Stroke, 2000;31:169
  2. Modification of behavioral effects of drugs in mice by neuroactive steroids.
    Ungard et al.
    Psychopharmacology, 2000;148:336
  3. Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor.
    Carter et al.
    J.Pharmacol.Exp.Ther., 1997;280:1284
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