Ganaxolone

Tocris Bioscience | Catalog # 2531

Potent positive allosteric modulator of GABAA receptors
Tocris Bioscience

Key Product Details

Description

Potent positive allosteric modulator of GABAA receptors

Alternative Names

CCD 1042
View all GABA-A Receptor Modulators »

Product Description

Ganaxolone is a potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Product Specifications for Ganaxolone

Molecular Weight

332.53

Formula

C22H36O2

Storage

Store at +4°C

Chemical Name

(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one

CAS Number

38398-32-2

PubChem ID

6918305

InChI Key

PGTVWKLGGCQMBR-FLBATMFCSA-N

SMILES

O[C@]1(C)CC[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.33 10 with gentle warming
Ethanol 6.65 20

Preparing Stock Solutions for Ganaxolone

The following data is based on the product molecular weight 332.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.04 mL 75.18 mL 150.36 mL
1 mM 3.01 mL 15.04 mL 30.07 mL
2 mM 1.50 mL 7.52 mL 15.04 mL
10 mM 0.30 mL 1.50 mL 3.01 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

Product Documents for Ganaxolone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ganaxolone

For research use only

Related Research Areas

GABA Receptors

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