Ganaxolone

  ( 1 citations )    
Product Datasheet
Catalog Number:2531
Alternate Names:CCD 1042
Chemical Name:(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
Product Details
Citations (1)
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Reviews
Biological Activity
Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Technical Data
  • M.Wt:
    332.53
  • Formula:
    C22H36O2
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 20 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    38398-32-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ganaxolone include:

1 Citations: Showing 1 - 1

  1. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546

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