GM2A Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-87090

Novus Biologicals
100% Guarantee

Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all GM2A Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: EPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GM2A Antibody - BSA Free

GM2A Antibody - BSA Free Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Analysis in human skin and skeletal muscle tissues Corresponding GM2A RNA-seq data are presented for the same tissues.
GM2A Antibody - BSA Free Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Staining of human skin shows strong granular cytoplasmic positivity in squamous epithelial cells.
GM2A Antibody - BSA Free Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
GM2A Antibody - BSA Free Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
GM2A Antibody - BSA Free Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Immunohistochemistry-Paraffin: GM2A Antibody - BSA Free [NBP1-87090]

Staining of human lymph node shows strong granular cytoplasmic positivity in germinal center cells.
GM2A Antibody - BSA Free Western Blot: GM2A Antibody - BSA Free [NBP1-87090]

Western Blot: GM2A Antibody - BSA Free [NBP1-87090]

Analysis in human cell lines SK-MEL-30 and MCF-7 using Anti-GM2A antibody. Corresponding GM2A RNA-seq data are presented for the same cell lines. Loading control: Anti-PFN1.

Applications for GM2A Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GM2A

GM2A, also known as Ganglioside GM2 activator, is a 193 amino acid that is 21 kDa, with lysosome subcellular location, acts as s a lipid transfer protein that stimulates the enzymatic processing of gangliosides and T-cell activation; acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A which, together with this activator, catalyzes the degradation of the ganglioside GM2; also displays some calcium-independent phospholipase activity. Disease research on this protein has shown a relationship with tay-sachs disease, gangliosidosis, gangliosidosis gm2, sandhoff disease, neurological disorder, candidiasis, protein s deficiency, neurodegenerative disease, tay-sachs disease ab variant, spinal muscular atrophy, lysosomal storage disease, muscular atrophy, sinusitis, gastric cancer, cholesterol, and neuronitis. The GM2A protein has also shown an interaction with PLD2, GPLD1 and HEXA in the Sphingolipid metabolism, glycosphingolipid metabolism, lysosome, and phospholipid metabolism pathways.

Alternate Names

Cerebroside sulfate activator protein, ganglioside GM2 activator, GM2 ganglioside activator, GM2-AP, SAP-3GM2 ganglioside activator protein, Shingolipid activator protein 3, sphingolipid activator protein 3

Gene Symbol

GM2A

Additional GM2A Products

Product Documents for GM2A Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for GM2A Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customer Reviews for GM2A Antibody - BSA Free

There are currently no reviews for this product. Be the first to review GM2A Antibody - BSA Free and earn rewards!

Have you used GM2A Antibody - BSA Free?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

No product specific FAQs exist for this product.

View all FAQs for Antibodies