Hesperadin hydrochloride

Catalog # Availability Size / Price Qty
3988/10
3988/50
Hesperadin hydrochloride | Aurora Kinase Inhibitors
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Description: Potent Aurora kinase B inhibitor

Chemical Name: N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide hydrochloride

Purity: ≥99%

Product Details
Reviews

Biological Activity

ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol- and taxol-treated HeLa cells. Inhibits replication of influenza A and B viral strains (IC50 values range from 0.22 μM to 1.8 μM, dependant on strain), by inhibiting viral RNA transcription and translation

Technical Data

M.Wt:
553.12
Formula:
C29H32N4O3S.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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