HGFR/c-MET Antibody (S02-4D6)

Name: HGFR/c-MET Antibody (S02-4D6)
Brand: Novus Biologicals
SKU: NBP3-14873
Price: 489 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-14873

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-4D6 expressed in HEK293

View all HGFR/c-MET Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human HGFR/c-MET (Uniprot#: P08581)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

170 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for HGFR/c-MET Antibody (S02-4D6)

Western Blot: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873]

Western Blot: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873] - Western blot detection of HGFR/c-MET in K562, C6, 3T3 cell lysates using HGFR/c-MET Rabbit mAb (1:1000 diluted). Predicted band size: 156kDa. Observed band size: 170kDa.

Immunocytochemistry/ Immunofluorescence: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873]

Immunocytochemistry/Immunofluorescence: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873] - Immunofluorescence of HGFR/c-MET (green) in Hela cells using HGFR/c-MET Rabbit mAb at dilution 1/200, and DAPI (blue)

Immunohistochemistry-Paraffin: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873]

Immunohistochemistry-Paraffin: HGFR/c-MET Antibody (S02-4D6) [NBP3-14873] - Immunohistochemistry of HGFR/c-MET in paraffin-embedded Human lung cancer tissue using HGFR/c-MET Rabbit mAb at dilution 1/5

Applications for HGFR/c-MET Antibody (S02-4D6)

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

1/20-1/100

Immunohistochemistry

1/20-1/50

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1/1000-1/2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HGFR/c-MET

Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)

Long Name

Hepatocyte Growth Factor Receptor

Alternate Names

c-MET, cMET, HGF R, MET

Gene Symbol

MET

Additional HGFR/c-MET Products

Product Documents for HGFR/c-MET Antibody (S02-4D6)

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Certificate of Analysis

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Product Specific Notices for HGFR/c-MET Antibody (S02-4D6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.