Human Amyloid beta (aa1-42) Quantikine ELISA Kit Summary
(aa1-42) showed linear curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human Amyloid beta (aa1-42).
Cell Culture Supernates, Tissue Lysates, Cerebrospinal Fluid
|Intra-Assay Precision||Inter-Assay Precision|
The recovery of human Amyloid beta (aa1-42) spiked to levels throughout the range of the assay in various matrices was evaluated.
|Sample Type||Average % Recovery||Range %|
|Cell Culture Media (n=4)||97||82-114|
|Cell Lysis Buffer (n=2)||92||90-94|
|Cerebrospinal Fluid (n=4)||107||95-120|
Human Amyloid beta aa 1-42 ELISA Standard Curve
Preparation and Storage
Background: Amyloid beta
Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.
Citations for Human Amyloid beta (aa1-42) Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 5
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The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro
Authors: P Liu, X Chen, H Zhou, L Wang, Z Zhang, X Ren, F Zhu, Y Guo, X Huang, J Liu, PS Spencer, X Yang
Oxid Med Cell Longev, 2018;2018(0):2025914.
Sample Types: Cell Lysates
MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism
Authors: T Suganuma, SK Swanson, M Gogol, TJ Garrett, J Conkright-, L Florens, MP Washburn, JL Workman
Cell Rep, 2018;24(6):1585-1596.
Sample Types: Cell Lysates
The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease
Authors: C Huang, H Chu, Y Ma, Z Zhou, C Dai, X Huang, L Fang, Q Ao, D Huang
Brain Stimul, 2018;0(0):.
Sample Types: Cell Lysate
HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease
Authors: X Zhu, S Wang, L Yu, J Jin, X Ye, Y Liu, Y Xu
Aging Cell, 2017;0(0):.
Sample Types: Tissue Homogenates
Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI
Sci Rep, 2016;6(0):37486.
Sample Types: Serum
Which form of A-beta (1-42) - monomer or oligomer - is detectable in Catalog # DAB142 (Human Amyloid beta (aa1-42) Quantikine ELISA kit)?
The Human Amyloid beta (aa1-42) Quantikine ELISA kit recognizes both monomers and oligomers of Human Amyloid beta (aa1-42). The standard in the kit is synthetic human Amyloid beta peptide that cannot oligomerize.
Supplemental ELISA Products
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