Human beta 2-Microglobulin Parameter Assay Kit

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Human beta 2-Microglobulin Parameter Assay Kit Summary

Assay Length
1.5 hours
Sample Type & Volume Required Per Well
Serum (20 uL), EDTA Plasma (20 uL), Heparin Plasma (20 uL), Urine (10 uL)
0.132 ug/mL
Assay Range
0.2 - 10 ug/mL (Serum, EDTA Plasma, Heparin Plasma, Urine)
Measures Human beta 2M levels in various samples.
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
No significant interference observed with available related molecules.

Product Summary

The Parameter beta 2-Microglobulin Immunoassay is a 1.5 hour forward sequential competitive enzyme immunoassay designed to measure beta 2M in serum, plasma, and urine.


The recovery of human beta 2M spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
EDTA Plasma (n=4) 99 79-114
Heparin Plasma (n=4) 106 91-124
Serum (n=4) 101 85-122
Urine (n=4) 90 76-105


To assess the linearity of the assay, samples containing and/or spiked with high concentrations of human beta 2M were serially diluted with calibrator diluent to produce samples with values within the dynamic range of the assay.
Human  beta 2-Microglobulin Assay Linearity

Scientific Data

Human beta 2-Microglobulin Assay ELISA Standard Curve

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Preparation and Storage

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: beta 2-Microglobulin

beta 2-Microglobulin (B2M) forms the light chain of Class I MHC molecules. It has been measured in a variety of body fluids, including serum/plasma, saliva, CSF, and urine. B2M freely passes through the glomerular membrane, but it is nearly completely reabsorbed and degraded in proximal tubule cells. Clinically, serum B2M is elevated in rheumatoid arthritis, systemic lupus erythematosus, viral infections, and conditions associated with decreased glomerular filtration.

Entrez Gene IDs:
567 (Human); 12010 (Mouse); 24223 (Rat); 101867173 (Cynomolgus Monkey)
Alternate Names:
B2M; beta 2Microglobulin; beta 2-Microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Citations for Human beta 2-Microglobulin Parameter Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation
    Authors: SK Heo, EK Noh, YJ Lee, Y Shin, Y Kim, HS Im, H Kim, SJ Koh, YJ Min, JC Jo, Y Choi
    BMC Cancer, 2022-09-20;22(1):997.
    Species: Human
    Sample Types: Plasma
  2. Stacking Machine Learning Algorithms for Biomarker-Based Preoperative Diagnosis of a Pelvic Mass
    Authors: R Shaw, AE Lokshin, MC Miller, G Messerlian, RG Moore
    Cancers, 2022-03-02;14(5):.
    Species: Human
    Sample Types: Serum
  3. Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors
    Authors: E Latoch, K Kono?czuk, K Taranta-Ja, K Muszy?ska-, M Sawicka, A Wasilewska, M Krawczuk-R
    Journal of Clinical Medicine, 2021-11-13;10(22):.
    Species: Human
    Sample Types: Urine
  4. Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL)
    Authors: A Sitlinger, MA Deal, E Garcia, DK Thompson, T Stewart, GA MacDonald, N Devos, D Corcoran, JS Staats, J Enzor, KJ Weinhold, DM Brander, JB Weinberg, DB Bartlett
    Cells, 2021-05-11;10(5):.
    Species: Human
    Sample Types: Plasma
  5. Multiple biomarker algorithms to predict epithelial ovarian cancer in women with a pelvic mass: Can additional makers improve performance?
    Authors: RG Moore, A Blackman, MC Miller, K Robison, PA DiSilvestr, EE Eklund, R Strongin, G Messerlian
    Gynecol. Oncol., 2019-04-13;0(0):.
    Species: Human
    Sample Types: Serum


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Human beta 2-Microglobulin Parameter Assay Kit
By Anonymous on 07/06/2021
Sample Tested: Serum and Plasma

we used this kit to quantify beta 2 microglobulin in human serum and plasma samples. Works very well and easy to use protocol.

Human beta 2-Microglobulin Parameter Assay Kit
By Anonymous on 08/23/2016
Sample Tested: Human Dialysate