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Human CCL2/MCP-1 Biotinylated Fluorokine Flow Cytometry Kit

Catalog #: NFCP0
5 Citations Datasheet / COA / SDS

Discontinued Product

NFCP0 has been discontinued.
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Citations (5)
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Summary Product Datasheets Background

Human CCL2/MCP-1 Biotinylated Fluorokine Flow Cytometry Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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COA
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Background: CCL2/JE/MCP-1

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Entrez Gene IDs
6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
Alternate Names
C-C motif chemokine ligand 2; CCL2; GDCF-2; HC11; HSMCR30; MCAF; Mcp1; MCP-1; SCYA2; SMC-CF

Citations for Human CCL2/MCP-1 Biotinylated Fluorokine Flow Cytometry Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. The GHS-R blocker D-[Lys3] GHRP-6 serves as CCR5 chemokine receptor antagonist.
    Authors: Patel K, Dixit VD, Lee JH, Kim JW, Schaffer EM, Nguyen D, Taub DD
    Int J Med Sci, 2011-11-18;9(1):51-8.  2011-11-18
  2. Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells.
    Authors: Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N
    Int. J. Cancer, 2010-03-01;126(5):1095-108.  2010-03-01
  3. The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities.
    Authors: Barroso-Gonzalez J, El Jaber-Vazdekis N, Garcia-Exposito L, Machado JD, Zarate R, Ravelo AG, Estevez-Braun A, Valenzuela-Fernandez A
    J. Biol. Chem., 2009-04-22;284(24):16609-20.  2009-04-22
  4. Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis.
    Authors: McIntosh LM, Barnes JL, Barnes VL, McDonald JR
    Clin. Exp. Immunol., 2008-11-25;155(2):295-303.  2008-11-25
  5. Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells.
    Authors: Brown CE, Vishwanath RP, Aguilar B, Starr R, Najbauer J, Aboody KS, Jensen MC
    J. Immunol., 2007-09-01;179(5):3332-41.  2007-09-01

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