Human CCL2/MCP-1 Primer Pair

Human CCL2/MCP-1 Primer Pair Summary

Specifications

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Background: CCL2/JE/MCP-1

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Related Research Areas

• Alpha Granule Soluble Molecules
• CC Chemokines and Receptors
• Chemokines and Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• gamma delta T Cells
• HIF Transcription Factors
• Inflammatory Mediators
• Macrophage Activation Markers
• Microglia Activation Markers
• Microglia Development
• Molecules Secreted by VSMC
• Neuroinflammatory Factors
• Uptake of Amyloid beta by Macrophages