Human CCR10 PE-conjugated Antibody

(12 citations)   
  • Species Reactivity
    Human
  • Specificity
    Detect human CCR10. Stains human CCR10-transfected cells but not irrelevant transfectants.
  • Source
    Monoclonal Rat IgG2A Clone # 314305
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Y3 rat myeloid cell line transfected with human CCR10
    Gln8-Asn362
    Accession # P46092
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Phycoerythrin
Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of CCR10 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD3 epsilon APC‑conjugated Monoclonal Antibody (Catalog # FAB100A) and either (A) Rat Anti-Human CCR10 PE‑conjugated Monoclonal Antibody (Catalog # FAB3478P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.
Detection of CCR10 in L1.2 Mouse Cell Line Transfected with Human CCR10 and eGFP by Flow Cytometry. L1.2 mouse pro-B cell line transfected with human CCR10 and eGFP was stained with either (A) Rat Anti-Human CCR10 PE‑conjugated Monoclonal Antibody (Catalog # FAB3478P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR10

CCR10 is a G protein-linked seven transmembrane domain protein expressed by T cells and B cell subsets that functions as a receptor for CCL27 and CCL28. CCR10 mediates lymphocyte migration to the skin and mucosa, and its expression is correlated with the metastatic behavior of melanomas.

  • Entrez Gene IDs:
    2826 (Human); 12777 (Mouse); 363682 (Rat)
  • Alternate Names:
    CC chemokine receptor 10; C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR10; CCR-10; chemokine (C-C motif) receptor 10; G protein-coupled receptor 2; GPR2; GPR2G-protein coupled receptor 2
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Skewing towards Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis
    Authors: W Szczeklik, B Jakie?a, K Wawrzycka-, M Sanak, M Hubalewska, A Padjas, M Surmiak, K Szczeklik, J Sznajd, J Musia?
    Eur. J. Immunol, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  2. Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition
    Authors: G Picarda, C Chéneau, JM Humbert, G Bériou, P Pilet, J Martin, F Duteille, P Perrot, F Bellier-Wa, M Heslan, F Haspot, F Guillon, R Josien, FA Halary
    J Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  3. The oral commensal Streptococcus mitis shows a mixed memory Th cell signature that is similar to and cross-reactive with Streptococcus pneumoniae.
    Authors: Engen S, Valen Rukke H, Becattini S, Jarrossay D, Blix I, Petersen F, Sallusto F, Schenck K
    PLoS ONE, 2014;9(8):e104306.
    Species: Human
    Sample Type: Whole Cells
    Application: IP
  4. CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.
    Authors: Buckner, Clarisa, Moir, Susan, Kardava, Lela, Ho, Jason, Santich, Brian H, Kim, Leo Jin, Funk, Emily K, Nelson, Amy K, Winckler, Britanny, Chairez, Cheryl L, Theobald-Whiting, Narda L, Anaya-O'Brien, Sandra, Alimchandani, Meghna, Quezado, Martha M, Yao, Michael, Kovacs, Joseph A, Chun, Tae-Wook, Fauci, Anthony, Malech, Harry L, De Ravin, Suk See
    J Allergy Clin Immunol, 2014;133(6):1676-85.e5.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  5. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
    Authors: Pinto S, Martinez-Romero A, O'Connor J, Gil-Benso R, San-Miguel T, Terradez L, Monteagudo C, Callaghan R
    BMC Cancer, 2014;14(0):118.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  6. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
    Authors: Tang, Xin-Zi, Jo, Juandy, Tan, Anthony, Sandalova, Elena, Chia, Adeline, Tan, Kai Chah, Lee, Kang Hoe, Gehring, Adam J, De Libero, Gennaro, Bertoletti, Antonio
    J Immunol, 2013;190(7):3142-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  7. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.
    Authors: Duhen T, Duhen R, Lanzavecchia A
    Blood, 2012;119(19):4430-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  8. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis.
    Authors: Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, Yamagami H, Watanabe K, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
    Clin. Exp. Immunol., 2011;163(2):215-24.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  9. Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab.
    Authors: Mei HE, Frolich D, Giesecke C, Loddenkemper C, Reiter K, Schmidt S, Feist E, Daridon C, Tony HP, Radbruch A, Dorner T
    Blood, 2010;116(24):5181-90.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  10. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
    Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
    J. Immunol., 2010;184(6):2886-98.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  11. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
    Authors: Carbone T, Nasorri F, Pennino D
    J. Immunol., 2010;184(2):1102-10.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
  12. Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES.
    Authors: Kroeze KL, Jurgens WJ, Doulabi BZ, van Milligen FJ, Scheper RJ, Gibbs S
    J. Invest. Dermatol., 2009;129(6):1569-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow
Expand to show all 12 Citations
Isotype Controls
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Rat IgG2A PE-conjugated Antibody

Ctrl IC006P 16  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 6
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 4
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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