CCR3 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Human CCR3 is 355 amino acids (aa) in length with a predicted molecular weight of 41 kDa. Mouse and rat CCR3 share 70% and 68% aa sequence identity with the human protein, respectively. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CCR3
Alternate Names
CCR3, CD193
Gene Symbol
CCR3
UniProt
Additional CCR3 Products
Product Documents for Human CCR3 (NP_001828) VersaClone cDNA
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Human CCR3 (NP_001828) VersaClone cDNA
For research use only
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