Human CD11b/Integrin alpha M Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD11b/Integrin alpha M

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesive Interactions in Allergy and Asthma
• B Cell Chemotaxis, Migration, and Adhesion
• B Cell Markers
• Basophils
• Common Macrophage Markers
• Conventional/Classical Dendritic Cells
• Granulocyte Markers
• Inflammatory/Monocyte-derived Dendritic Cells
• Integrins and Associated Molecules
• Isolation, Culture, and Identification of Natural Killer Cells
• Langerhans and Dermal Dendritic Cells
• Microglia Activation
• Microglia Steady-State Markers
• Monocyte Markers
• Mouse Tissue-Resident Macrophage Markers
• Myeloid Lineage Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Neutrophils
• Plasmacytoid Dendritic Cells
• T Cell Migration/Adhesion
• Uptake of Amyloid beta by Glia Cells