Human CD11b/Integrin alpha M Antibody
Human CD11b/Integrin alpha M Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CD11b/Integrin alpha M in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human CD11b/Integrin alpha M Monoclonal Antibody (Catalog # MAB1699, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.
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CD11b/Integrin alpha M in Human PBMCs. CD11b/Integrin aM was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Mouse Anti-Human CD11b/Integrin aM Monoclonal Antibody (Catalog # MAB1699) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD11b/Integrin alpha M
The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.
Product Datasheets
Citations for Human CD11b/Integrin alpha M Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
Authors: D Stacey, L Chen, PJ Stanczyk, JMM Howson, AM Mason, S Burgess, S MacDonald, J Langdown, H McKinney, K Downes, N Farahi, JE Peters, S Basu, JS Pankow, W Tang, N Pankratz, M Sabater-Ll, PS de Vries, NL Smith, CHARGE Hem, AD Gelinas, DJ Schneider, N Janjic, NJ Samani, S Ye, C Summers, ER Chilvers, J Danesh, DS Paul
Nature Communications, 2022;13(1):1222.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Activation of the plasma kallikrein-kinin system on human lung epithelial cells.
Authors: Vergiliana JF, Asokananthan N, Stewart GA
Biol. Chem., 2010;391(9):1067-77.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells.
Authors: Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL
J. Immunol., 2010;184(8):4557-67.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
Immunology, 2004;112(2):274-89.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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