Detection of Integrin alpha M/CD11b in Human Blood Monocytes by Flow Cytometry.
Human peripheral blood monocytes were stained with Mouse Anti-Human Integrin alpha M/CD11b Alexa Fluor® 700‑conjugated Monoclonal Antibody (Catalog # FAB1699N, filled histogram) or isotype control antibody (Catalog # IC002N, open histogram). View our protocol for Staining Intracellular Molecules.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: CD11b/Integrin alpha M
The Integrin family proteins are heterodimeric transmembrane receptors
composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known
as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit
(CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known
as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is
expressed on granulocytes, macrophages, dendritic cells and natural
killer cells. Upon activation, alpha M/ beta 2 can bind several ligands
(including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to
mediate phagocyte adhesion, migration and ingestion of
Entrez Gene IDs:
3684 (Human); 16409 (Mouse)
antigen CD11b (p170); CD11 antigen-like family member B; CD11b antigen; CD11b; CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide); Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; CR3AMGC117044; Integrin alpha M; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MO1A; neutrophil adherence receptor alpha-M subunit; Neutrophil adherence receptor; SLEB6
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