Human CD11b/Integrin alpha M Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry View Larger

Detection of Integrin alpha M/CD11b in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human Integrin alpha M/CD11b Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB1699N, filled histogram) or isotype control antibody (Catalog # IC002N, open histogram). View our protocol for Staining Intracellular Molecules.

Preparation and Storage

Background: CD11b/Integrin alpha M

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alpha M subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimer Integrin alpha M/ beta 2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alpha M/ beta 2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alpha M/ beta 2 can bind several ligands (including ICAM-1 fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesive Interactions in Allergy and Asthma
• B Cell Chemotaxis, Migration, and Adhesion
• B Cell Markers
• Basophils
• Common Macrophage Markers
• Conventional/Classical Dendritic Cells
• Granulocyte Markers
• Inflammatory/Monocyte-derived Dendritic Cells
• Integrins and Associated Molecules
• Isolation, Culture, and Identification of Natural Killer Cells
• Langerhans and Dermal Dendritic Cells
• Microglia Activation
• Microglia Steady-State Markers
• Monocyte Markers
• Mouse Tissue-Resident Macrophage Markers
• Myeloid Lineage Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Neutrophils
• Plasmacytoid Dendritic Cells
• T Cell Migration/Adhesion
• Uptake of Amyloid beta by Glia Cells