Human CD157 Antibody Summary
Accession # Q10588
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human CD157 by Western Blot. Western blot shows lysates of human kidney (cortex) tissue. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human CD157 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4736) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for CD157 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CD157, also known as bone marrow stromal cell antigen 1 (BST-1), is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family (1). CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth (2, 3). Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA‑derived bone marrow stromal cell lines (3). CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule (4).
- Hussain, A. M. M. et al. (1998) Protein Express. Purif. 12:133.
- Sato, A. et al. (1999) Biochem. J. 337:491.
- Kaisho, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91:5325.
- Ortolan, E. et al. (2002) Cell Biochem. Funct. 20:309.
Citations for Human CD157 Antibody
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Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcript
Authors: E Ferrero, N Lo Buono, S Morone, R Parrotta, C Mancini, A Brusco, A Giacomino, S Augeri, A Rosal-Vela, S García-Rod, M Zubiaur, J Sancho, A Fiorio Pla, A Funaro
Sci Rep, 2017;7(1):15923.
Sample Types: Cell Lysates
Applications: Western Blot
Binding of CD157 protein to fibronectin regulates cell adhesion and spreading.
Authors: Morone S, Augeri S, Cuccioloni M, Mozzicafreddo M, Angeletti M, Lo Buono N, Giacomino A, Ortolan E, Funaro A
J Biol Chem, 2014;289(22):15588-601.
Sample Types: Protein
Applications: ELISA Development (Capture)
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