Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2B Clone # 462608
View all CNP Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human CNP
Lys24-Cys126
Accession # P23582

Specificity

Detects human pro-CNP and mature CNP53 and CNP29 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) ANP or rhBNP is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications for Human CNP Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human CNP

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CNP

C-Type Natriuretic Peptide (CNP) belongs to the natriuretic peptide family and functions in an autocrine or paracrine fashion. CNP interacts with the GC-B/NPR-B receptor to promote vasorelaxation, vascular remodeling, and the growth and differentiation of bone and neural tissue. CNP is synthesized as a prohormone that is cleaved intracellularly by furin, yielding a 49 aa propeptide and a 53 aa mature peptide (CNP53). Additional cleavage of the mature peptide generates 29 aa and 22 aa peptides (CNP29 and CNP22) which have comparable activity in some assays. Within the 53 aa mature CNP, human shares 96% aa sequence identity with mouse and rat.

Long Name

C-type Natriuretic Peptide

Alternate Names

NPPC

Entrez Gene IDs

4880 (Human)

Gene Symbol

NPPC

UniProt

P23582

Additional CNP Products

Product Documents for Human CNP Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human CNP Antibody

For research use only

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FAQs

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