Human Endocan/ESM-1 Biotinylated Antibody

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Product Details
Supplemental Products

Human Endocan/ESM-1 Biotinylated Antibody Summary

Species Reactivity
Detects human Endocan/ESM‑1 in Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant human Endocan/ESM‑1
Accession # Q9NQ30
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human Endocan/ESM‑1 (Catalog # 1810-EC)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Endocan/ESM-1

Endocan, also known as endothelial-cell specific molecule-1 (ESM-1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung (1). Endocan expression has also been detected in different epithelia and in adipocytes (2, 3). The expression of endocan is up‑regulated by TNF alpha, IL-1 beta or lipopolysaccharide and down-regulated by IFN-gamma (1). The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues (1). The DS chain is covalently attached to serine 137 (4). Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen-1, LFA-1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA-1-mediated leukocyte activation (5). Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity (3, 6). Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo (3, 6). Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported (2, 6).

  1. Lassalle, P. et al. (1996) J. Biol. Chem. 271:20458.
  2. Bechard, D. et al. (2000) J. Vasc. Res. 37:417.
  3. Wellner, M. et al. (2003) Horm. Metab. Res. 35:217.
  4. Bechard, D. et al. (2001) J. Biol. Chem. 276:48341.
  5. Bechard, D. et al. (2001) J. Immunol. 167:3099
  6. Scherpereel, A. et al. (2003) Cancer Res. 63:6084.
Entrez Gene IDs
11082 (Human); 71690 (Mouse)
Alternate Names
Endocan; endothelial cell-specific molecule 1; ESM1; ESM-1; IGFBP-rp6

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