EPCR in Human Liver.
EPCR was detected in immersion fixed paraffin-embedded sections of human liver array using Goat Anti-Human EPCR Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF2245) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Protein C is a vitamin K-dependent serine protease that plays a major
role in blood coagulation. Binding of Protein C to EPCR leads to the
proteolytic activation of PAR1 (protease-activated receptor 1) on
endothelial cells and subsequent up-regulation of Protein C-induced
genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC
family. It is expressed most strongly in the endothelial cells of
arteries and veins in heart and lung. Membrane bound EPCR is released
by metalloproteolytic cleavage to generate the soluble receptor. The
extracellular domain of human and mouse EPCR shares approximately 61%
amino acid sequence homology.
Endothelial Protein C Receptor
Entrez Gene IDs:
10544 (Human); 19124 (Mouse)
APC receptor; CCCA; CCD41; CCD41centrosome-associated protein; CD201 antigen; CD201; centrocyclin; Endothelial cell protein C receptor; endothelial protein C receptor; EPCR; EPCRMGC23024; PROCR; protein C receptor, endothelial
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