Human FRA-1 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FRA-1

FRA-1 is a member of the leucine zipper Fos family of transcription factors. Fos family members have been associated with cellular proliferation, differentiation and transformation. In accordance with these findings, overexpression of FRA-1 correlates with a malignant phenotype in breast cancer. In lung epithelia cells, FRA-1 promotes motility, invasion, and anchorage independent growth. FRA-1 knock out mice rescued for the FRA-1 placental defect are viable but show reduced bone formation that may be due to a defect in the osteoblast differentiation.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Basic Leucine Zipper (bZIP) Transcription Factors
• Cancer Stem Cell Transcription Factors
• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• NOD-like Receptors and the Inflammasome
• Toll-Like Receptors
• Transcription Factors in the Akt Pathway
• VEGF Family