Human GABA-A R alpha 5 (NP_000801) VersaClone cDNA

Catalog # Availability Size / Price Qty
RDC0899
R&D Systems VersaClone cDNA Plasmids
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Human GABA-A R alpha 5 (NP_000801) VersaClone cDNA Summary

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

The rat α5 isoform is a 439 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 25 - 232). The α5 subunit is unusual in that it contains an N-terminal histidine which renders it very sensitive to zinc. It is also associated with extrasynaptic sites and seems to mediate tonic inhibition in hippocampal neurons.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: GABA-A R alpha 5

Long Name
gamma-Aminobutyric Acid Type A Receptor, alpha-5 Polypeptide
Entrez Gene IDs
2558 (Human); 110886 (Mouse); 29707 (Rat)
Alternate Names
GABA A R alpha 5; GABA(A) receptor subunit alpha-5; GABAAR alpha 5; GABAARa5; GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; MGC138184

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