Human GABA-A R beta 3 (NP_000805) VersaClone cDNA

Name: Human GABA-A R beta 3 (NP_000805) VersaClone cDNA
Brand: R&D Systems
SKU: RDC0835
Price: 270 USD
Availability: InStock

R&D Systems | Catalog # RDC0835

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Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species

Human

Accession Number

NP_000805

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: GABA A R alpha 3

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003).

Long Name

gamma-Aminobutyric Acid Type A Receptor, alpha-3 Polypeptide

Alternate Names

GABAARa3, GABRA3

Entrez Gene IDs

2556 (Human); 14396 (Mouse); 24947 (Rat)

Gene Symbol

GABRA3

UniProt

NP_000805

Additional GABA A R alpha 3 Products

Product Documents for Human GABA-A R beta 3 (NP_000805) VersaClone cDNA

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Certificate of Analysis

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Product Specific Notices for Human GABA-A R beta 3 (NP_000805) VersaClone cDNA

For research use only

Related Research Areas

GABA Receptors

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