Human GATA-6 ExactaChIP Chromatin IP Kit

Human GATA-6 ExactaChIP Chromatin IP Kit Summary

Specifications

Product Datasheets

Background: GATA-6

GATA proteins are transcriptional coactivators with two GATA-type zinc fingers. GATAs bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. GATA-1, -2, -3 are selectively expressed in hematopoietic and endothelial cells, while GATA-4, -5, and -6 are expressed in developing heart and gut-derived tissues. GATA-1 and -3 exist in multiple alternatively spliced isoforms.

GATA-6 (also named GATA-GT1) is a zinc finger transcription activating protein that binds to a T/A-G-A-T-A-G/A DNA sequence motif in mesodermally and endodermally-derived tissue. There are two GATA-6 isoforms that arise from alternate start sites: a short form of 449 amino acids (aa), and a long form of 595 aa. The short form of human GATA-6 is 93%, 92% and 88% aa identical to GATA-6 in porcine, rat, and mouse, respectively.

Related Research Areas

• Cardiac Stem Cell Markers
• Early Endodermal Lineage Markers
• Epithelial Stem Cell Transcription Factors
• GATA Transcription Factors
• Mesenchymal Stem Cell Transcription Factors
• Mouse Tissue-Resident Macrophage Markers
• Primitive Endoderm Markers
• Transcription Factors in the Akt Pathway
• Transcription Regulators in VSMC