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Human GM-CSF Luminex Performance Assay

Catalog #: LUH215C Datasheet / COA / SDS

Discontinued Product

LUH215C has been discontinued and is replaced by LUHM215.

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Human GM-CSF Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: GM-CSF

GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the inflammatory activation of dendritic cells, microglia, alveolar macrophages, and eosinophils. In addition, it cooperates with G-CSF in promoting tumor cell proliferation and invasion. GM-CSF signals through a receptor complex composed of GM-CSF R alpha and the Common beta Chain (beta c) with Syndecan-2 as a potential co-receptor. The beta c subunit is shared by the receptor complexes for IL-3 and IL-5.

Long Name
Granulocyte Macrophage Growth Factor
Entrez Gene IDs
1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
Alternate Names
colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; CSF-2; GMCSF; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; Molgramostim; molgramostin; Sargramostim

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Product Specific Notices
Luminex® is a registered trademark of Luminex Corporation.

Citations for Human GM-CSF Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. REDD1 protects osteoblast cells from gamma radiation-induced premature senescence.
    Authors: Li XH, Ha CT, Fu D, Xiao M
    PLoS ONE, 2012-05-18;7(5):e36604.
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions.
    Authors: Murciano C, Moyes DL, Runglall M, Tobouti P, Islam A, Hoyer LL, Naglik JR
    PLoS ONE, 2012-03-12;7(3):e33362.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  4. Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.
    Authors: Moyes DL, Murciano C, Runglall M, Islam A, Thavaraj S, Naglik JR
    PLoS ONE, 2011-11-08;6(11):e26580.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
    Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
    PLoS ONE, 2011-06-08;6(6):e20541.
    Species: Human
    Sample Types: Serum
  7. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010-03-25;115(24):5041-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Clinical efficacy and immune regulation with peanut oral immunotherapy.
    Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
    J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
    Authors: O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE
    Proc. Natl. Acad. Sci. U.S.A., 2009-03-30;106(15):6099-104.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.
    Authors: Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, Scott McIvor R, Wagner JE, Blazar BR, Zhou X
    Mol. Ther., 2008-01-29;16(3):580-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.
    Authors: Jenkins C, Garcia W, Godwin MJ, Spencer JV, Stern JL, Abendroth A, Slobedman B
    J. Virol., 2008-01-23;82(7):3736-50.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients.
    Authors: Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Ward C, Lordan JL
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-01-18;294(3):L592-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. Increased frequency of CD4+ cells expressing CD161 in cancer patients.
    Authors: Iliopoulou EG, Karamouzis MV, Missitzis I, Ardavanis A, Sotiriadou NN, Baxevanis CN, Rigatos G, Papamichail M, Perez SA
    Clin. Cancer Res., 2006-12-01;12(23):6901-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  14. A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55.
    Authors: Ullenhag GJ, Spendlove I, Watson NF, Indar AA, Dube M, Robins RA, Maxwell-Armstrong C, Scholefield JH, Durrant LG
    Clin. Cancer Res., 2006-11-22;12(24):7389-96.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity.
    Authors: Tomic J, White D, Shi Y, Mena J, Hammond C, He L, Miller RL, Spaner DE
    J. Immunol., 2006-03-15;176(6):3830-9.
    Species: Human
    Sample Types: Cell Culture Supernates

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