Human IFN-beta ELISA Kit

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Newer Version Available: DIFNB0
NEW
NEW Human IFN-beta Quantikine ELISA Kit is now available!
Catalog # Availability Size / Price Qty
41410-2
41410-1

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Product Details
Citations (30)
FAQs
Supplemental Products
Reviews (1)

Human IFN-beta ELISA Kit Summary

Assay Length
3.25 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL)
Sensitivity
50 pg/mL
Assay Range
50.0 - 4,000 pg/mL (Cell Culture Supernates)
Specificity
Human IFN-beta
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name:
Interferon beta
Entrez Gene IDs:
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names:
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Citations for Human IFN-beta ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

30 Citations: Showing 1 - 10
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  1. STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases
    Authors: Ferecsk�, AS;Smallwood, MJ;Moore, A;Liddle, C;Newcombe, J;Holley, J;Whatmore, J;Gutowski, NJ;Eggleton, P;
    Biomedicines
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
    Authors: X Kong, X Lu, S Wang, J Hao, D Guo, H Wu, Y Jiang, Y Sun, J Wang, G Zhang, Z Cai
    Cell Reports, 2023-01-19;42(1):112002.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  3. DDX41 is required for cGAS-STING activation against DNA virus infection
    Authors: RS Singh, V Vidhyasaga, S Yang, AB Arna, M Yadav, A Aggarwal, AN Aguilera, S Shinriki, KK Bhanumathy, K Pandey, A Xu, N Rapin, M Bosch, J DeCoteau, J Xiang, FJ Vizeacouma, Y Zhou, V Misra, H Matsui, SR Ross, Y Wu
    Cell Reports, 2022-05-24;39(8):110856.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO
    Authors: J Wu, Y Shi, X Pan, S Wu, R Hou, Y Zhang, T Zhong, H Tang, W Du, L Wang, J Wo, J Mu, Y Qiu, K Yang, LK Zhang, BC Ye, N Qi
    Cell Reports, 2021-02-03;34(7):108761.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
    Authors: S Ding, J Diep, N Feng, L Ren, B Li, YS Ooi, X Wang, KF Brulois, LL Yasukawa, X Li, CJ Kuo, DA Solomon, JE Carette, HB Greenberg
    Nat Commun, 2018-04-16;9(1):1485.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. Surface Toll-Like Receptor 3 Expression in Metastatic Intestinal Epithelial Cells induces Inflammatory Cytokine Production and Promotes Invasiveness
    Authors: M Bugge, B Bergstrom, OK Eide, H Solli, IF Kjønstad, J Stenvik, T Espevik, NJ Nilsen
    J. Biol. Chem., 2017-07-17;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
    Proc Natl Acad Sci USA, 2016-09-06;113(38):10625-10630.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5
    PLoS ONE, 2016-08-09;11(8):e0160875.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
    PLoS Pathog, 2016-07-28;12(7):e1005770.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  10. Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner
    Authors: M Tatematsu, R Yoshida, Y Morioka, N Ishii, K Funami, A Watanabe, K Saeki, T Seya, M Matsumoto
    J Immunol, 2016-03-28;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium.
    Authors: Villenave R, Broadbent L, Douglas I, Lyons J, Coyle P, Teng M, Tripp R, Heaney L, Shields M, Power U
    J Virol, 2015-09-30;89(24):12309-18.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer.
    Authors: Hosein A, Livingstone J, Buchanan M, Reid J, Hallett M, Basik M
    BMC Cancer, 2015-03-15;15(0):130.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
    Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
    J Virol, 2015-01-21;89(7):3859-69.
    Species: Human
    Sample Types: Cell Culture Supernates
  14. Natural killer cells can inhibit the transmission of human cytomegalovirus in cell culture by using mechanisms from innate and adaptive immune responses.
    Authors: Wu Z, Sinzger C, Reichel J, Just M, Mertens T
    J Virol, 2014-12-24;89(5):2906-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
    Authors: Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S
    Eur J Immunol, 2014-12-23;45(3):758-72.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection.
    Authors: Zhang Y, Yeruva L, Marinov A, Prantner D, Wyrick P, Lupashin V, Nagarajan U
    J Immunol, 2014-07-28;193(5):2394-404.
    Species: Human
    Sample Types: Cell Culture Supernates
  17. HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-beta induction in cervical epithelial cells.
    Authors: Liu H, Chen K, Feng W, Guo J, Li H
    PLoS ONE, 2014-04-10;9(4):e94806.
    Species: Human
    Sample Types: Cell Culture Supernates
  18. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling.
    Authors: Xia, Mao, Gonzalez, Patrick, Li, Chunyan, Meng, Gang, Jiang, Aiqin, Wang, Hongwei, Gao, Qian, Debatin, Klaus-Mi, Beltinger, Christia, Wei, Jiwu
    J Virol, 2014-02-26;88(9):5152-64.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells.
    Authors: Stone, Amy E L, Giugliano, Silvia, Schnell, Gretja, Cheng, Linling, Leahy, Katelyn, Golden-Mason, Lucy, Gale, Michael, Rosen, Hugo R
    PLoS Pathog, 2013-04-18;9(4):e1003316.
    Species: Human
    Sample Types: Cell Culture Supernates
  20. Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.
    Authors: Patel MV, Ghosh M, Fahey JV, Wira CR
    PLoS ONE, 2012-04-25;7(4):e35654.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
    Authors: Wang P, Arjona A, Zhang Y
    Nat. Immunol., 2010-09-05;11(10):912-9.
    Species: Mouse
    Sample Types: Plasma
  22. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010-03-25;115(24):5041-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
    Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
    J. Allergy Clin. Immunol., 2009-06-27;124(2):260-9, 269.e1.
    Species: Human
    Sample Types: Serum
  24. Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans.
    Authors: Schirmer SH, van Royen N, Moerland PD, Fledderus JO, Henriques JP, van der Schaaf RJ, Vis MM, Baan J, Koch KT, Horrevoets AJ, Hoefer IE, Piek JJ
    J. Am. Coll. Cardiol., 2009-06-09;53(23):2141-7.
    Species: Human
    Sample Types: Plasma
  25. The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
    Authors: Lee SH, Kim JS, Jun HK
    J. Immunol., 2009-05-01;182(9):5823-35.
    Species: Human
    Sample Types: Cell Lysates
  26. Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4.
    Authors: Chase JC, Celli J, Bosio CM
    Infect. Immun., 2008-11-03;77(1):180-95.
    Species: Human
    Sample Types: Cell Culture Supernates
  27. Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.
    Authors: Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007-07-13;293(4):L1021-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  28. Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
    Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
    Clin. Exp. Immunol., 2007-01-01;147(1):71-80.
    Species: Human
    Sample Types: Serum
  29. Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.
    Authors: Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M
    J. Gen. Virol., 2004-09-01;85(0):2603-13.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.
    Authors: Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ
    J. Immunol., 2004-01-01;172(1):138-43.
    Species: Human
    Sample Types: Cell Culture Supernates

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Human IFN-beta ELISA Kit
By Anonymous on 07/11/2019
Sample Tested: BMEC