Human IFN-gamma Quantikine ELISA Kit

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DIF50C
SIF50C
PDIF50C
Control Products Available
Human IFN-gamma ELISA Standard Curve
4 Images
Product Details
Citations (140)
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Human IFN-gamma Quantikine ELISA Kit Summary

Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL), Serum (100 uL), EDTA Plasma (100 uL), Heparin Plasma (100 uL)
Sensitivity
5.69 pg/mL
Assay Range
15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
Specificity
Natural and recombinant human IFN-gamma.
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine® Human IFN-gamma Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IFN-gamma levels in cell culture supernates, serum, and plasma. It contains HEK293-expressed recombinant human IFN-gamma and antibodies raised against the recombinant factor. Results obtained for naturally occurring human IFN-gamma samples showed linear curves that were parallel to the standard curves obtained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IFN-gamma.

Precision

Intra-Assay Precision (Precision within an assay) <div>Three samples of known concentration were tested twenty times on one plate to assess&nbsp;intra-assay precision.</div>
Inter-Assay Precision (Precision between assays) <div>Three samples of known concentration were tested in twenty separate assays to assess&nbsp;inter-assay precision. Assays were performed by at least three technicians using two lots of components.</div>

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean 153 366 720 154 366 723
Standard Deviation 3.47 9.16 19.4 9.9 20.6 54
CV% 2.3 2.5 2.7 6.4 5.6 7.5

Recovery

The recovery of human IFN-gamma spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 91 84-106
EDTA Plasma (n=4) 95 85-105
Heparin Plasma (n=4) 96 87-101
Serum (n=4) 95 90-109

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of human IFN-gamma in various matrices were diluted with calibrator diluent to produce samples with values within the dynamic range of the assay. 
Human IFN-gamma ELISA Linearity
Human IFN-gamma  Linearity Curve Quantikine ELISA

Data Examples

Human IFN-gamma ELISA Standard Curve

Human IFN-gamma Standard Curve ELISA

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IFN-gamma

Interferon-gamma (IFN-gamma ) is an important immunomodulatory cytokine, affecting both the innate and adaptive immune systems. It was discovered in 1965 as a soluble anti-viral factor and has since been shown to promote host defense against a wide variety of pathogens (1, 2). Additionally, it has been shown to promote autophagy and apoptosis, and to have anti-proliferative, anti-angiogenic, and anti-tumorigenic properties (1, 3, 4). IFN-gamma is primarily secreted by natural killer (NK) cells (5-7), activated CD8+ T cells (8), Th1 CD4+ T cells (9), NKT cells (10, 11), and macrophages (12-16), but it has also been shown to be produced by a number of other cell types including dendritic cells (17), gamma δ T cells (18), group 1 ILCs (19), keratinocytes (20), neutrophils (21), mast cells (22), and neurons (23). 

The biologically active form of IFN-gamma is a non-covalently linked homodimer (24), which binds with high affinity to IFN-gamma R1/CD119 and subsequently recruits IFN-gamma R2 to form the functional heterotetrameric receptor complex. Formation of this complex leads to phosphorylation and activation of the Janus kinases, Jak1 and Jak2, which in turn phosphorylate and activate STAT1. STAT1 homodimerizes and translocates to the nucleus where it binds to IFN-gamma -activated sequence (GAS) elements in the promoters of target genes to regulate their transcription. Many of the IFN-gamma /STAT1 target genes are transcription factors that then drive the expression of secondary response genes. Additionally, IFN-gamma signaling has been shown to activate MAPK, PI 3-K/Akt, and the NF-kappa B signaling pathways, leading to the expression of multiple other genes. IFN-gamma signaling plays a key role in host defense by promoting macrophage activation, upregulating the expression of antigen processing and presentation molecules, driving the development and activation of Th1 cells, enhancing natural killer cell activity, regulating B cell functions, and inducing the production of chemokines that promote effector cell trafficking to sites of inflammation. 
Due to its immunoregulatory activities, IFN-gamma has been used as a therapeutic agent for treating a range of bacterial, fungal, helminth, protozoan, and viral infections, immunodeficiency syndromes, multi-drug resistant tuberculosis (MDR-TB), and sepsis (1, 25-34). Additionally, it has been used as an anti-tumor agent to improve patient survival in a number of different types of cancer due to its pro-apoptotic and anti-angiogenic effects (3, 35). In contrast, IFN-gamma has been suggested to be involved in the progression of cardiac diseases as elevated levels of this cytokine have been detected in the serum of patients with chronic heart failure, as well as in atherosclerotic lesions and in myocardial tissues of patients with Chagas' cardiomyopathy (1, 36, 37). Similarly, high levels of IFN-gamma have been found in the serum and/or cerebrospinal fluid of patients with neurodegenerative diseases such as Amyotrophic lateral sclerosis and Parkinson's disease (38, 39), suggesting that IFN-gamma may also be involved in neurodegenerative disease progression and serve as a clinical biomarker. Additionally, there is recent evidence suggesting that IFN-gamma may also have context-dependent proliferative and pro-tumorigenic effects (3).

Long Name:
Interferon gamma
Entrez Gene IDs:
3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)

Citations for Human IFN-gamma Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

140 Citations: Showing 1 - 10
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  1. Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review
    Authors: M Herrera, C Vera, Y Keynan, ZV Rueda
    J Immunol Res, 2020;2020(0):8074183.
    Species: Human
    Sample Types: Plasma
  2. LIPUS vs. reaming in non-union treatment: Cytokine expression course as a tool for evaluation and differentiation of non-union therapy
    Authors: J Doll, A Moghaddam, V Daniel, B Biglari, R Heller, G Schmidmaie, TF Raven
    J Orthop, 2020;17(0):208-214.
    Species: Human
    Sample Types: Serum
  3. MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma
    Authors: Z Mei, K Zhang, AK Lam, J Huang, F Qiu, B Qiao, Y Zhang
    Cancer Med, 2019;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer
    Authors: MJ Kim, BH Chi, JJ Yoo, YM Ju, YM Whang, IH Chang
    PLoS ONE, 2019;14(10):e0223689.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women
    Authors: IS Ribeiro, ÍS Pereira, DP Santos, DS Lopes, AO Prado, SPM Calado, CV Gonçalves, MPL Galantini, IPR Muniz, GS Santos, RAA Silva
    Exp. Gerontol., 2019;127(0):110734.
    Species: Human
    Sample Types: Plasma
  6. The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis
    Authors: G Prencipe, C Bracaglia, I Caiello, A Pascarella, P Francalanc, M Pardeo, A Meneghel, G Martini, MN Rossi, A Insalaco, G Marucci, V Nobili, M Spada, F Zulian, F De Benedet
    PLoS ONE, 2019;14(12):e0226043.
    Species: Human
    Sample Types: Plasma
  7. N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNgamma-stimulated endothelial cells
    Authors: BB Hofmann, N Krapp, Y Li, C De La Torr, M Sol, JD Braun, M Kolibabka, P Pallavi, BK Krämer, BA Yard, AI Kälsch
    Sci Rep, 2019;9(1):19338.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Low-Dose Carbon Monoxide Inhibits Rhinovirus Replication in Human Alveolar and Airway Epithelial Cells
    Authors: X Deng, H Yasuda, T Sasaki, M Yamaya
    Tohoku J. Exp. Med., 2019;247(4):215-222.
    Species: Human
    Sample Types: Cell Lysates
  9. Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses
    Authors: H Yu, S Cui, Y Mei, Q Li, L Wu, S Duan, G Cai, H Zhu, B Fu, L Zhang, Z Feng, X Chen
    J Immunol Res, 2019;2019(0):2121849.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output
    Authors: E Terzuoli, C Bellan, S Aversa, V Ciccone, L Morbidelli, A Giachetti, S Donnini, M Ziche
    Cancers (Basel), 2019;11(12):.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture negative
    Authors: K Tashiro, M Yamamoto, R Ushio, N Kobayashi, T Sato, M Kudo, T Kaneko
    Int. J. Infect. Dis., 2019;86(0):47-54.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Evaluation of immunological, inflammatory, and oxidative stress biomarkers in gasoline station attendants
    Authors: AM Moro, E Sauer, N Brucker, MF Charão, B Gauer, SN do Nascime, G Goethel, MMMF Duarte, SC Garcia
    BMC Pharmacol Toxicol, 2019;20(0):75.
    Species: Human
    Sample Types: Serum
  13. Plasma levels of TNF-?, IL-6, IFN-?, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD)
    Authors: S Clayton, E Cauble, A Kumar, N Patil, D Ledford, N Kolliputi, MF Lopes-Vire, D Castell, J Richter
    BMC Gastroenterol, 2019;19(1):28.
    Species: Human
    Sample Types: Plasma
  14. Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function
    Authors: A Stiff, P Trikha, BL Mundy-Boss, EL McMichael, TA Mace, B Benner, K Kendra, A Campbell, S Gautam, D Abood, I Landi, V Hsu, MC Duggan, R Wesolowski, M Old, JH Howard, L Yu, N Stasik, T Olencki, N Muthusamy, S Tridandapa, JC Byrd, MA Caligiuri, WE Carson
    Clin. Cancer Res., 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects
    Authors: FN Osuji, CC Onyenekwe, JE Ahaneku, NR Ukibe
    J. Biomed. Sci., 2018;25(1):88.
    Species: Human
    Sample Types: Plasma
  16. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models
    Authors: Y Kagoya, M Nakatsugaw, K Saso, T Guo, M Anczurowsk, CH Wang, MO Butler, CH Arrowsmith, N Hirano
    Nat Commun, 2018;9(1):1915.
    Species: Mouse
    Sample Types: Serum
  17. Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells
    Authors: ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner
    Exp. Eye Res., 2018;170(0):29-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. Construction, Expression, and Characterization of rSEA-EGF and In Vitro Evaluation of its Antitumor Activity Against Nasopharyngeal Cancer
    Authors: X Liu, L Zeng, Z Zhao, Y Xie, S Wang, J Zhang, Y He, Z Zou, J Zhang, A Tao
    Technol. Cancer Res. Treat., 2018;17(0):1533033818762.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. Occupational exposure to ultrafine particles in police officers: no evidence for adverse respiratory effects
    Authors: G Jordakieva, I Grabovac, E Valic, KE Schmidt, A Graff, A Schuster, K Hoffmann-S, C Oberhuber, O Scheiner, A Goll, J Godnic-Cva
    J Occup Med Toxicol, 2018;13(0):5.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Capture
  20. Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation
    Authors: M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux
    J Cell Commun Signal, 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
    Authors: AS Sampaio, ALR Vasconcelo, CNL Morais, GTN Diniz, ALC Figueiredo, SML Montenegro
    Rev. Soc. Bras. Med. Trop., 2018;51(1):21-29.
    Species: Human
    Sample Types: Plasma
  22. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
    Authors: J Park, I Wetzel, I Marriott, D Dréau, C D'Avanzo, DY Kim, RE Tanzi, H Cho
    Nat. Neurosci., 2018;21(7):941-951.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro
    Authors: JH Kim, SJ Jang, JW Yun, MH Jung, SH Woo
    PLoS ONE, 2018;13(11):e0207090.
    Species: Human
    Sample Types: Whole Cells
  24. MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression - First results of a cross-sectional study
    Authors: G Schmalz, I Davarpanah, J Jäger, RF Mausberg, B Krohn-Grim, J Schmidt, R Haak, U Sack, D Ziebolz
    J Microbiol Immunol Infect, 2017;0(0):.
    Species: Human
    Sample Types: Serum
  25. Association between cytokine profile and transcription factors produced by T cells subsets in early and late-onset preeclampsia
    Authors: VR Ribeiro, M Romao-Veig, GG Romagnoli, ML Matias, PR Nunes, VTM Borges, JC Peracoli, MTS Peracoli
    Immunology, 2017;0(0):.
    Species: Human
    Sample Types: Plasma
  26. Frequency and role of NKp46 and NKG2A in hepatitis B virus infection
    Authors: T Yoshioka, T Tatsumi, T Miyagi, K Mukai, K Nishio, A Nishio, Y Yokoyama, T Suda, T Kegasawa, M Shigekawa, H Hikita, R Sakamori, T Takehara
    PLoS ONE, 2017;12(3):e0174103.
    Species: Human
    Sample Types: Cell Culture Supernates
  27. The in vitro and ex vivo effect of Auranta 3001 in preventing Cryptosporidium hominis and Cryptosporidium parvum infection
    Authors: A Ch Stratak, F Sima, P Ward, M Linton, C Kelly, L Pinkerton, L Stef, I Pet, T Iancu, G Pircalabio, N Corcionivo
    Gut Pathog, 2017;9(0):49.
    Species: Bovine
    Sample Types: Cell Culture Supernates
  28. Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer
    Authors: K Gonda, M Shibata, T Ohtake, Y Matsumoto, K Tachibana, N Abe, H Ohto, K Sakurai, S Takenoshit
    Oncol Lett, 2017;14(2):1766-1774.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome
    Authors: KC Clark, FA Fierro, EM Ko, NJ Walker, B Arzi, CG Tepper, H Dahlenburg, A Cicchetto, A Kol, L Marsh, WJ Murphy, N Fazel, DL Borjesson
    Stem Cell Res Ther, 2017;8(1):69.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab
    Authors: U Bughani, A Saha, A Kuriakose, R Nair, RB Sadashivar, R Venkataram, S Patel, AT Deshchougu, SK S, E Montero, HV Pai, DV Palanivelu, R Melarkode, P Nair
    PLoS ONE, 2017;12(7):e0180088.
    Species: Human
    Sample Types: Cell Culture Supernates
  31. Upregulated unique long 16 binding protein 1 detected in preeclamptic placenta affects human extravillous trophoblast cell line (HTR-8/SVneo) invasion by modulating the function of uterine natural killer cells
    Authors: J Liu, G Song, X Lin, X Pang, T Meng
    Exp Ther Med, 2017;13(4):1447-1455.
    Species: Human
    Sample Types: Cell Culture Supernates
  32. Alterations in the Fecal Microbiota of Patients with HIV-1 Infection: An Observational Study in A Chinese Population
    Sci Rep, 2016;6(0):30673.
    Species: Human
    Sample Types: Serum
  33. Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells
    Authors: Yadollah Omidi
    Biosens Bioelectron, 2016;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  34. Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia
    Authors: Farrukh T Awan
    Oncoimmunology, 2016;5(10):e1226720.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome
    J Immunol, 2016;197(5):1621-30.
    Species: Human
    Sample Types: Serum
  36. A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.
    Authors: Valton J, Guyot V, Marechal A, Filhol J, Juillerat A, Duclert A, Duchateau P, Poirot L
    Mol Ther, 2015;23(9):1507-18.
    Species: Human
    Sample Types: Cell Culture Supernates
  37. CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
    Authors: Li W, Liu H
    Scand J Immunol, 2015;83(1):33-7.
    Species: Human
    Sample Types: Tissue Homogenates
  38. A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism.
    Authors: Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, Genore L, Zaghloul D, Iaboni A, Marcon P, Anagnostou E
    Mol Autism, 2015;6(0):18.
    Species: Human
    Sample Types: Plasma
  39. Comparative Multi-Donor Study of IFNgamma Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
    Authors: Hagen J, Zimmerman R, Goetz C, Bonnevier J, Houchins J, Reagan K, Kalyuzhny A
    Cells, 2015;4(1):84-95.
    Species: Human
    Sample Types: Whole Cells
  40. WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features.
    Authors: Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z
    BMC Gastroenterol, 2015;15(0):173.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  41. Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma.
    Authors: Han L, Liu F, Li R, Li Z, Chen X, Zhou Z, Zhang X, Hu T, Zhang Y, Young K, Sun S, Wen J, Zhang M
    Oncol Lett, 2014;8(4):1461-1469.
    Species: Human
    Sample Types: Serum
  42. EBV-encoded miR-BART20-5p and miR-BART8 inhibit the IFN-gamma-STAT1 pathway associated with disease progression in nasal NK-cell lymphoma.
    Authors: Huang W, Lin C
    Am J Pathol, 2014;184(4):1185-97.
    Species: Human
    Sample Types: Cell Culture Supernates
  43. Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
    Authors: Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, Nie X, Du M, Li D, Zhang J
    PLoS ONE, 2014;9(6):e99612.
    Species: Human
    Sample Types: Cell Culture Supernates
  44. Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
    Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
    J Transl Med, 2014;12(1):330.
    Species: Human
    Sample Types: Serum
  45. Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses.
    Authors: Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw P, Locht C, Ausiello C
    PLoS ONE, 2014;9(6):e100166.
    Species: Human
    Sample Types: Cell Culture Supernates
  46. Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity.
    Authors: Krishnan G, Chatterjee N
    Mol Cell Neurosci, 2014;59(0):10-23.
    Species: Human
    Sample Types: Cell Culture Supernates
  47. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
    Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
    PLoS ONE, 2014;9(1):e86466.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Cleaved/associated TLR3 represents the primary form of the signaling receptor.
    Authors: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli M, Zhang S, Funami K, Seya T, Matsumoto M, Pin J, Casanova J, Renno T, Lebecque S
    J Immunol, 2013;190(2):764-73.
    Species: Human
    Sample Types: Cell Culture Supernates
  49. Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men.
    Authors: Weng T, Huang S, Chuang Y, Wang J
    PLoS ONE, 2013;8(11):e80248.
    Species: Human
    Sample Types: Plasma
  50. N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation.
    Authors: Ciaglia E, Pisanti S, Picardi P, Laezza C, Malfitano A, D'Alessandro A, Gazzerro P, Vitale M, Carbone E, Bifulco M
    J Leukoc Biol, 2013;94(6):1207-19.
    Species: Human
    Sample Types: Cell Culture Supernates
  51. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
    Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
    Hum Mol Genet, 2013;22(9):1807-15.
    Species: Human
    Sample Types: Serum
  52. Neutrophil microparticles modulate cytokine production by natural killer cells.
    Authors: Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V
    Cytokine, 2013;65(2):126-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  53. Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.
    Authors: Shukla N, Salunke D, Balakrishna R, Mutz C, Malladi S, David S
    PLoS ONE, 2012;7(8):e43612.
    Species: Human
    Sample Types: Cell Culture Supernates
  54. Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
    Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
    Blood, 2012;120(19):4058-67.
    Species: Human
    Sample Types: Serum
  55. Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
    Authors: Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, Buch MH, McDermott MF, Ponchel F
    Clin. Exp. Rheumatol., 2012;30(4):534-42.
    Species: Human
    Sample Types: Serum
  56. Analysis of the Interferon Gamma (rs2430561, +874T/A) Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis.
    Authors: Garcia-Bermudez M, Lopez-Mejias R, Gonzalez-Juanatey C, Corrales A, Robledo G, Castaneda S, Miranda-Filloy J, Blanco R, Fernandez-Gutierrez B, Balsa A, Gonzalez-Alvaro I, Gomez-Vaquero C, Llorca J, Martin J, Gonzalez-Gay M
    PLoS ONE, 2012;7(10):e47166.
    Species: Human
    Sample Types: Serum
  57. Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus.
    Authors: Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J
    J. Invest. Dermatol., 2011;131(1):133-40.
    Species: Human
    Sample Types: Cell Culture Supernates
  58. Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis.
    Authors: Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ
    Am. J. Pathol., 2011;178(2):744-53.
    Species: Human
    Sample Types: Whole Tissue
  59. Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
    Authors: Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H
    Arthritis Res. Ther., 2011;13(2):R52.
    Species: Human
    Sample Types: Serum
  60. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties.
    Authors: Brandau S, Trellakis S, Bruderek K, Schmaltz D, Steller G, Elian M, Suttmann H, Schenck M, Welling J, Zabel P, Lang S
    J. Leukoc. Biol., 2011;89(2):311-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  61. HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
    Authors: Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC
    Leukemia, 2011;25(1):161-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  62. Identification of human NK17/NK1 cells.
    Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
    PLoS ONE, 2011;6(10):e26780.
    Species: Human
    Sample Types: Cell Culture Supernates
  63. Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system.
    Authors: Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X
    PLoS ONE, 2011;6(9):e24751.
    Species: Human
    Sample Types: Cell Culture Supernates
  64. Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults.
    Authors: Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS
    PLoS ONE, 2011;6(10):e26050.
    Species: Human
    Sample Types: Plasma
  65. Subnormal cytokine profile in the tear fluid of keratoconus patients.
    Authors: Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S
    PLoS ONE, 2011;6(1):e16437.
    Species: Human
    Sample Types: Tears
  66. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
    Authors: Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M
    Diabetes, 2010;59(4):829-35.
    Species: Human
    Sample Types: Plasma
  67. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
    Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG
    J. Immunol., 2010;184(3):1642-52.
    Species: Human
    Sample Types: Serum
  68. A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function.
    Authors: Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J
    Biochem. Pharmacol., 2010;79(2):188-97.
    Species: Human
    Sample Types: Cell Culture Supernates
  69. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
    Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
    J. Allergy Clin. Immunol., 2010;126(5):962.
    Species: Human
    Sample Types: Tissue Homogenates
  70. B7-h3 augments the inflammatory response and is associated with human sepsis.
    Authors: Zhang G, Wang J, Kelly J
    J. Immunol., 2010;185(6):3677-84.
    Species: Human
    Sample Types: Plasma
  71. Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
    Authors: Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N
    Clin. Immunol., 2010;135(3):364-73.
    Species: Human
    Sample Types: Cell Culture Supernates
  72. Interleukin-1beta, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis.
    Authors: Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P
    J. Interferon Cytokine Res., 2010;30(11):835-42.
    Species: Human
    Sample Types: Serum
  73. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
    Authors: Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC
    Cancer Res., 2009;69(4):1553-60.
    Species: Human
    Sample Types: Plasma
  74. Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
    Authors: Oh JY, Kim MK, Shin MS, Wee WR, Lee JH
    Cytokine, 2009;46(1):100-3.
    Species: Human
    Sample Types: Cell Culture Supernates
  75. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
    Species: Human
    Sample Types: Cell Culture Supernates
  76. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
    Authors: Mabilleau G, Sabokbar A
    PLoS ONE, 2009;4(1):e4173.
    Species: Human
    Sample Types: Cell Culture Supernates
  77. Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis.
    Authors: Niederfuhr A, Kirsche H, Deutschle T, Poppert S, Riechelmann H, Wellinghausen N
    Allergy, 2008;63(10):1359-67.
    Species: Human
    Sample Types: Nasal Lavage Fluid
  78. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
    Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
    Eur. J. Immunol., 2008;38(4):1012-23.
    Species: Human
    Sample Types: Cell Culture Supernates
  79. Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
    Authors: Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, Son Y, Tajima K, Liu YJ, Ito T, Fukuhara S
    Int. Immunol., 2008;20(10):1321-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  80. Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis.
    Authors: Stefanescu R, Bassett D, Modarresi R, Santiago F, Fakruddin M, Laurence J
    Blood, 2008;112(2):340-9.
    Species: Human
    Sample Types: Plasma
  81. An evaluation of commercial fluorescent bead-based luminex cytokine assays.
    Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
    PLoS ONE, 2008;3(7):e2535.
    Species: Human
    Sample Types: Cell Culture Supernates
  82. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
    Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
    J. Immunol., 2008;181(11):8053-67.
    Species: Human
    Sample Types: BALF
  83. Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
    Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
    Clin. Exp. Immunol., 2007;147(1):71-80.
    Species: Human
    Sample Types: Serum
  84. Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma.
    Authors: Little RF, Aleman K, Kumar P, Wyvill KM, Pluda JM, Read-Connole E, Wang V, Pittaluga S, Catanzaro AT, Steinberg SM, Yarchoan R
    Blood, 2007;110(13):4165-71.
    Species: Human
    Sample Types: Serum
  85. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
    Authors: Lin YL, Liang YC, Chiang BL
    J. Leukoc. Biol., 2007;82(6):1473-80.
    Species: Human
    Sample Types: Cell Culture Supernates
  86. Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.
    Authors: Mian MF, Lauzon NM, Stampfli MR, Mossman KL, Ashkar AA
    J. Leukoc. Biol., 2007;83(3):774-84.
    Species: Human
    Sample Types: Cell Culture Supernates
  87. Translocation of bacterial DNA from Gram-positive microorganisms is associated with a species-specific inflammatory response in serum and ascitic fluid of patients with cirrhosis.
    Authors: Frances R, Gonzalez-Navajas JM, Zapater P, Munoz C, Cano R, Pascual S, Santana F, Marquez D, Perez-Mateo M, Such J
    Clin. Exp. Immunol., 2007;150(2):230-7.
    Species: Human
    Sample Types: Serum
  88. 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
    Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
    Cytokine, 2007;40(2):128-34.
    Species: Human
    Sample Types: Cell Culture Supernates
  89. Panel of markers can accurately predict endometriosis in a subset of patients.
    Authors: Seeber B, Sammel MD, Fan X, Gerton GL, Shaunik A, Chittams J, Barnhart KT
    Fertil. Steril., 2007;89(5):1073-81.
    Species: Human
    Sample Types: Serum
  90. Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
    Authors: Irhimeh MR, Fitton JH, Lowenthal RM
    Exp. Hematol., 2007;35(6):989-94.
    Species: Human
    Sample Types: Plasma
  91. Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection.
    Authors: Clay CC, Rodrigues DS, Ho YS, Fallert BA, Janatpour K, Reinhart TA, Esser U
    J. Virol., 2007;81(21):12040-8.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  92. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
    Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
    J. Immunol., 2007;178(9):5973-81.
    Species: Human
    Sample Types: Cell Culture Supernates
  93. CD200 is induced by ERK and is a potential therapeutic target in melanoma.
    Authors: Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE
    J. Clin. Invest., 2007;117(12):3922-3929.
    Species: Human
    Sample Types: Cell Culture Supernates
  94. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
    Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
    Blood, 2006;107(5):1955-62.
    Species: Human
    Sample Types: Cell Culture Supernates
  95. Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo.
    Authors: Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, MacKenzie KL, Vermeulen PB, Jackson P, Russell PJ
    Biochem. Biophys. Res. Commun., 2006;345(3):1207-14.
    Species: Human
    Sample Types: Cell Culture Supernates
  96. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
    Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
    Clin. Cancer Res., 2006;12(2):376-82.
    Species: Human
    Sample Types: Plasma
  97. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006;172(1):156-65.
    Species: Human
    Sample Types: Serum
  98. Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
    Authors: Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M
    Am. J. Respir. Crit. Care Med., 2006;173(12):1370-6.
    Species: Human
    Sample Types: Serum
  99. Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma.
    Authors: Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, Watanabe H, Takaoka S, Suzuki Y, Takamori M, Yamada M
    J. Neuroimmunol., 2006;175(1):169-75.
    Species: Human
    Sample Types: Serum
  100. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
    Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
    Gut, 2006;56(2):243-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  101. Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock.
    Authors: Claessens YE, Fontenay M, Pene F, Chiche JD, Guesnu M, Hababou C, Casadevall N, Dhainaut JF, Mira JP, Cariou A
    Am. J. Respir. Crit. Care Med., 2006;174(1):51-7.
    Species: Human
    Sample Types: Plasma
  102. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
    Authors: Ebert EC, Mehta V
    Cell. Immunol., 2006;241(1):7-13.
    Species: Human
    Sample Types: Cell Culture Supernates
  103. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
    Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2006;36(5):1309-23.
    Species: Human
    Sample Types: Plasma
  104. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
    Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
    Blood, 2006;107(9):3617-23.
    Species: Human
    Sample Types: Cell Culture Supernates
  105. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
    Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
    Blood, 2006;108(3):947-55.
    Species: Human
    Sample Types: Cell Culture Supernates
  106. Effect of piceatannol in human monocyte-derived dendritic cells in vitro.
    Authors: Takei M, Umeyama A, Arihara S, Matsumoto H
    J Pharm Sci, 2005;94(5):974-82.
    Species: Human
    Sample Types: Cell Culture Supernates
  107. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
    Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
    Microbes Infect., 2005;7(3):427-36.
    Species: Human
    Sample Types: Serum
  108. Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
    Authors: Jensen J, Krakauer M, Sellebjerg F
    Cytokine, 2005;29(1):24-30.
    Species: Human
    Sample Types: Plasma
  109. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
    Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
    Microbes Infect., 2005;7(3):427-36.
    Species: Human
    Sample Types: Serum
  110. Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
    Authors: Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I
    J. Allergy Clin. Immunol., 2005;116(4):805-11.
    Species: Human
    Sample Types: Tissue Secretion
  111. Detection of interleukin 10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
    Authors: Mistchenko AS, Fornari MC, Viegas M, Barrero PR, Diez RA
    J. Neurovirol., 2005;11(1):66-9.
    Species: Human
    Sample Types: CSF
  112. Effects of antiasthmatic agents on the functions of peripheral blood monocyte-derived dendritic cells from atopic patients.
    Authors: Saeki S, Matsuse H, Kondo Y, Machida I, Kawano T, Tomari S, Obase Y, Fukushima C, Kohno S
    J. Allergy Clin. Immunol., 2004;114(3):538-44.
    Species: Human
    Sample Types: Cell Culture Supernates
  113. A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors.
    Authors: Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J, Santos OF, Bustamante J, Levy J, Candotti F, Casanova JL
    Blood, 2004;104(7):2095-101.
    Species: Human
    Sample Types: Cell Culture Supernates
  114. Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries.
    Authors: Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL
    J. Androl., 2004;25(2):250-4.
    Species: Human
    Sample Types: Seminal Plasma
  115. Escape from cardiomyocyte apoptosis by enterovirus persistence due to elevated soluble Fas-receptors.
    Authors: Alter P, Maisch B
    Z Kardiol, 2004;93(7):524-32.
    Species: Human
    Sample Types: Serum
  116. Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: a pilot study.
    Authors: Ciprandi G, Tosca MA, Milanese M, Caligo G, Ricca V
    Pediatr Allergy Immunol, 2004;15(2):148-51.
    Species: Human
    Sample Types: Nasal Lavage Fluid
  117. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
    Authors: Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC
    Cancer Res., 2004;64(24):9160-6.
    Species: Human
    Sample Types: Cell Culture Supernates
  118. IL-22 increases the innate immunity of tissues.
    Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
    Immunity, 2004;21(2):241-54.
    Species: Human
    Sample Types: Cell Culture Supernates
  119. Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18.
    Authors: Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC
    J. Med. Virol., 2004;73(2):289-94.
    Species: Human
    Sample Types: Tissue Secretion
  120. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.
    Authors: Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y
    Blood, 2003;102(12):4084-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  121. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
    Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
    J. Leukoc. Biol., 2003;73(5):584-90.
    Species: Human
    Sample Types: Cell Culture Supernates
  122. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction.
    Authors: Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T
    J. Immunol., 2003;170(11):5571-7.
    Species: Human
    Sample Types: Cell Culture Supernates
  123. Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma.
    Authors: Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G
    Int. J. Cancer, 2002;101(2):183-9.
    Species: Human
    Sample Types: Ascites Fluid
  124. Cytokine profile in Behcet's disease patients. Relationship with disease activity.
    Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
    Scand. J. Rheumatol., 2002;31(4):205-10.
    Species: Human
    Sample Types: Serum
  125. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
    Authors: Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O&amp;amp;apos;Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW
    J. Immunol., 2002;168(11):5699-708.
    Species: Human
    Sample Types: Cell Culture Supernates
  126. Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
    Authors: Briard D, Brouty-Boye D, Azzarone B, Jasmin C
    J. Immunol., 2002;168(9):4326-32.
    Species: Human
    Sample Types: Cell Culture Supernates
  127. Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.
    Authors: D&amp;amp;apos;Ambrosio D
    Eur. J. Immunol., 2002;32(10):2934-43.
    Species: Human
    Sample Types: Cell Culture Supernates
  128. Cytokine pattern in blister fluid and sera of patients with pemphigus.
    Authors: Baroni A, Perfetto B, Ruocco E, Greco R, Criscuolo D, Ruocco V
    Dermatology (Basel), 2002;205(2):116-21.
    Species: Human
    Sample Types: Blister Fluid
  129. Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells.
    Authors: Lazetic S, Leong SR, Chang JC, Ong R, Dawes G, Punnonen J
    J. Biol. Chem., 2002;277(41):38660-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  130. The significance of cytokines, chemical composition, and murine embryo development in hydrosalpinx fluid for predicting the IVF outcome in women with hydrosalpinx.
    Authors: Chen CD, Yang JH, Lin KC, Chao KH, Ho HN, Yang YS
    Hum. Reprod., 2002;17(1):128-33.
    Species: Human
    Sample Types: Hydrosalpinx Fluid
  131. Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies.
    Authors: Jotwani R, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, Banchereau J, Cutler CW
    J. Immunol., 2001;167(8):4693-700.
    Species: Human
    Sample Types: Gingival Crevicular Fluid (GCF)
  132. Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses.
    Authors: Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A
    Infect. Immun., 2001;69(1):288-96.
    Species: Human
    Sample Types: Cell Culture Supernates
  133. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases.
    Authors: Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G
    J. Leukoc. Biol., 2001;70(4):617-23.
    Species: Human
    Sample Types: Cell Culture Supernates
  134. An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon.
    Authors: Cotler SJ, Reddy KR, McCone J, Wolfe DL, Liu A, Craft TR, Ferris MW, Conrad AJ, Albrecht J, Morrissey M, Ganger DR, Rosenblate H, Blatt LM, Jensen DM, Taylor MW
    J. Interferon Cytokine Res., 2001;21(12):1011-9.
    Species: Human
    Sample Types: Serum
  135. Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity.
    Authors: Black, K P, Merrill, K W, Jackson, S, Katz, J
    Oral Microbiol Immunol, 2000;15(2):74-81.
    Species: Human
    Sample Types: Saliva
  136. Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
    Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
    J. Exp. Med., 2000;192(2):219-26.
    Species: Human
    Sample Types: Cell Culture Supernates
  137. Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2.
    Authors: Chen YM, Ting CC, Peng JW, Yang WK, Yang KY, Tsai CM, Perng RP
    J. Interferon Cytokine Res., 2000;20(1):31-9.
    Species: Human
    Sample Types: Pleural Effusion
  138. Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis.
    Authors: Benson M, Strannegard IL, Wennergren G, Strannegard O
    Pediatr Allergy Immunol, 2000;11(1):20-8.
    Species: Human
    Sample Types: Nasal Lavage Fluid
  139. Cytokine production in rhesus monkeys infected with Plasmodium coatneyi.
    Authors: Yang C, Xiao L, Tongren JE, Sullivan J, Lal AA, Collins WE
    Am. J. Trop. Med. Hyg., 1999;61(2):226-9.
    Species: Primate
    Sample Types: Serum
  140. VSIG-3 as a ligand of VISTA inhibits human T-cell function.
    Authors: Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V
    Immunology, 0;156(1):74-85.
    Species: Human
    Sample Types: Cell Culture Supernates

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