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Human IL-10 Luminex Performance Assay

Catalog #: LUH217 Datasheet / COA / SDS

Discontinued Product

LUH217 has been discontinued and is replaced by LUHM217.

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Human IL-10 Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IL-10

Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.

Long Name
Interleukin 10
Entrez Gene IDs
3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 102133450 (Cynomolgus Monkey); 100034187 (Equine); 493683 (Feline); 100715618 (Guinea Pig); 2949786 (Viral)
Alternate Names
CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; GVHDS; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF

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Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IL-10 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

35 Citations: Showing 1 - 10
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  1. Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.
    Authors: Stoppelkamp S, Veseli K, Stang K, Schlensak C, Wendel H, Walker T
    PLoS ONE, 2015-08-11;10(8):e0135527.
    Species: Human
    Sample Types: Plasma
  2. Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue.
    Authors: Beck I, Van Crombruggen K, Holtappels G, Daubeuf F, Frossard N, Bachert C, De Bosscher K
    PLoS ONE, 2015-04-13;10(4):e0123068.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans.
    Authors: Lorthioir A, Joannides R, Remy-Jouet I, Freguin-Bouilland C, Iacob M, Roche C, Monteil C, Lucas D, Renet S, Audrezet M, Godin M, Richard V, Thuillez C, Guerrot D, Bellien J
    Kidney Int, 2014-07-16;87(2):465-72.
    Species: Human
    Sample Types: Plasma
  4. Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.
    Authors: Chantratita N, Tandhavanant S, Myers N, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle L, Ernst R, Emond M, Wurfel M, Day N, Peacock S, West T
    PLoS ONE, 2013-11-26;8(11):e81617.
    Species: Human
    Sample Types: Plasma
  5. ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death.
    Authors: Garg, Abhishek, Dudek, Aleksand, Ferreira, Gabriela, Verfaillie, Tom, Vandenabeele, Peter, Krysko, Dmitri V, Mathieu, Chantal, Agostinis, Patrizia
    Autophagy, 2013-06-19;9(9):1292-307.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. Sputum IgE and cytokines in asthma: relationship with sputum cellular profile.
    Authors: Manise M, Holtappels G, Van Crombruggen K, Schleich F, Bachert C, Louis R
    PLoS ONE, 2013-03-26;8(0):U111.
    Species: Human
    Sample Types: Sputum
  7. Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
    Authors: Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C
    J Immunol, 2013-03-15;190(8):4420-30.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  9. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
    Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
    PLoS ONE, 2011-06-08;6(6):e20541.
    Species: Human
    Sample Types: Serum
  11. Effect of Lactobacillus paracasei ST11 on a nasal provocation test with grass pollen in allergic rhinitis.
    Authors: Wassenberg J, Nutten S, Audran R, Barbier N, Aubert V, Moulin J, Mercenier A, Spertini F
    Clin. Exp. Allergy, 2011-04-01;41(4):565-73.
    Species: Human
    Sample Types: Nasal Fluid
  12. Probiotic Lactobacillus casei Shirota supplementation does not modulate immunity in healthy men with reduced natural killer cell activity.
    Authors: Seifert S, Bub A, Franz CM, Watzl B
    J. Nutr., 2011-03-23;141(5):978-84.
    Species: Human
    Sample Types: Cell Culture Supernates
  13. The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.
    Authors: Durig J, Duhrsen U, Klein-Hitpass L, Worm J, Hansen JB, Orum H, Wissenbach M
    Leukemia, 2011-03-01;25(4):638-47.
    Species: Human
    Sample Types: Serum
  14. Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4.
    Authors: Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum W, Seissler J, Kolb H, Hunter S, Leslie RD, Schloot NC
    Diabetologia, 2011-02-24;54(7):1630-8.
    Species: Human
    Sample Types: Serum
  15. Lipid-heparin infusion suppresses the IL-10 response to trauma in subcutaneous adipose tissue in humans.
    Authors: Ikeoka DT, Pachler C, Mader JK, Bock G, Neves AL, Svehlikova E, Feichtner F, Koehler G, Wrighton CJ, Pieber TR, Ellmerer M
    Obesity (Silver Spring), 2010-11-18;19(4):715-21.
    Species: Human
    Sample Types: Complex Sample Type
  16. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
    Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
    Eur. J. Immunol., 2010-09-01;40(9):2450-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  17. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010-03-25;115(24):5041-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  18. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
    Authors: Hergenroeder GW, Moore AN, McCoy JP
    J Neuroinflammation, 2010-03-11;7(0):19.
    Species: Human
    Sample Types: Serum
  19. Remodeling of skeletal muscle microvasculature in sickle cell trait and alpha-thalassemia.
    Authors: Vincent L, Feasson L, Oyono-Enguelle S, Banimbek V, Denis C, Guarneri C, Aufradet E, Monchanin G, Martin C, Gozal D, Dohbobga M, Wouassi D, Garet M, Thiriet P, Messonnier L
    Am. J. Physiol. Heart Circ. Physiol., 2009-11-13;298(2):H375-84.
    Species: Human
    Sample Types: Plasma
  20. The ssRNA genome of human rhinovirus induces a type I IFN response but fails to induce maturation in human monocyte-derived dendritic cells.
    Authors: Schrauf C, Kirchberger S, Majdic O, Seyerl M, Zlabinger GJ, Stuhlmeier KM, Sachet M, Seipelt J, Stockl J
    J. Immunol., 2009-09-04;183(7):4440-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. Clinical efficacy and immune regulation with peanut oral immunotherapy.
    Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
    J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
    Species: Human
    Sample Types: Cell Culture Supernates
  22. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
    Authors: Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF
    Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14.
    Species: Human
    Sample Types: BALF
  23. Cigarette smoke facilitates allergen penetration across respiratory epithelium.
    Authors: Gangl K, Reininger R, Bernhard D, Campana R, Pree I, Reisinger J, Kneidinger M, Kundi M, Dolznig H, Thurnher D, Valent P, Chen KW, Vrtala S, Spitzauer S, Valenta R, Niederberger V
    Allergy, 2008-12-16;64(3):398-405.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. NF-kappaB modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gammadelta lymphocytes.
    Authors: Ferrarini M, Delfanti F, Gianolini M, Rizzi C, Alfano M, Lazzarin A, Biswas P
    J. Immunol., 2008-11-01;181(9):5857-64.
    Species: Human
    Sample Types: Cell Culture Supernates
  25. Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.
    Authors: El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, Clouet-Delannoy M, Lombardelli L, Jabrane-Ferrat N, Rukavina D, Bensussan A, Piccinni MP, Le Bouteiller P, Tabiasco J
    J. Immunol., 2008-09-01;181(0):3009-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. An evaluation of commercial fluorescent bead-based luminex cytokine assays.
    Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
    PLoS ONE, 2008-07-02;3(7):e2535.
    Species: Human
    Sample Types: Serum
  27. The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.
    Authors: Mittermann I, Reininger R, Zimmermann M, Gangl K, Reisinger J, Aichberger KJ, Greisenegger EK, Niederberger V, Seipelt J, Bohle B, Kopp T, Akdis CA, Spitzauer S, Valent P, Valenta R
    J. Invest. Dermatol., 2007-12-13;128(6):1451-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  28. Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock.
    Authors: Sunden-Cullberg J, Nystrom T, Lee ML, Mullins GE, Tokics L, Andersson J, Norrby-Teglund A, Treutiger CJ
    Crit. Care Med., 2007-06-01;35(6):1536-42.
    Species: Human
    Sample Types: Serum
  29. Increased frequency of CD4+ cells expressing CD161 in cancer patients.
    Authors: Iliopoulou EG, Karamouzis MV, Missitzis I, Ardavanis A, Sotiriadou NN, Baxevanis CN, Rigatos G, Papamichail M, Perez SA
    Clin. Cancer Res., 2006-12-01;12(23):6901-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55.
    Authors: Ullenhag GJ, Spendlove I, Watson NF, Indar AA, Dube M, Robins RA, Maxwell-Armstrong C, Scholefield JH, Durrant LG
    Clin. Cancer Res., 2006-11-22;12(24):7389-96.
    Species: Human
    Sample Types: Cell Culture Supernates
  31. Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers.
    Authors: Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S
    J. Allergy Clin. Immunol., 2006-04-27;117(6):1396-403.
    Species: Human
    Sample Types: Saliva
  32. Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells.
    Authors: Jewett A, Cacalano NA, Head C, Teruel A
    Clin. Cancer Res., 2006-04-01;12(7):1994-2003.
    Species: Human
    Sample Types: Cell Culture Supernates
  33. Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity.
    Authors: Tomic J, White D, Shi Y, Mena J, Hammond C, He L, Miller RL, Spaner DE
    J. Immunol., 2006-03-15;176(6):3830-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  34. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.
    Authors: Razonable RR, Henault M, Lee LN, Laethem C, Johnston PA, Watson HL, Paya CV
    Antimicrob. Agents Chemother., 2005-04-01;49(4):1617-21.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
    Authors: Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W
    J. Immunol., 2004-10-01;173(7):4433-42.
    Species: Human
    Sample Types: Cell Culture Supernates

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