Human IL-2 Luminex Performance Assay

Name: Human IL-2 Luminex Performance Assay
Brand: R&D Systems
SKU: LUH202

Catalog #: LUH202 Datasheet / COA / SDS

Discontinued Product

LUH202 has been discontinued and is replaced by LUHM202.

R&D Systems Luminex High Performance Panel

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Citations (20)

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Human IL-2 Luminex Performance Assay Summary

Assay Type	bead-based multiplex assay for the Luminex^® platform
Format	1 x 96-well microplate and antibody-coated beads
Analytes Detected	Please see analyte list in assay customization tool below.
Performance Validation	Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

Not finding your analyte of interest? View our complete Luminex offering in the full version of our Luminex Assay Customization Tool. We also offer Custom Luminex Services.

Which Luminex Assay is right for me?

Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IL-2

IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c). IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.

Long Name

Interleukin 2

Entrez Gene IDs

3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)

Alternate Names

Aldesleukin; IL2; IL-2; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; Proleukin; T cell growth factor; T-cell growth factor; TCGF

Product Datasheets

COA

SDS

Product Specific Notices

Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IL-2 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.
Authors: Stoppelkamp S, Veseli K, Stang K, Schlensak C, Wendel H, Walker T
PLoS ONE, 2015-08-11;10(8):e0135527.
Species: Human
Sample Types: Plasma
Differential cytokine profiles upon comparing selective versus classic glucocorticoid receptor modulation in human peripheral blood mononuclear cells and inferior turbinate tissue.
Authors: Beck I, Van Crombruggen K, Holtappels G, Daubeuf F, Frossard N, Bachert C, De Bosscher K
PLoS ONE, 2015-04-13;10(4):e0123068.
Species: Human
Sample Types: Cell Culture Supernates
The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica.
Authors: Libraty DH, Makela S, Vlk J, Hurme M, Vaheri A, Ennis FA, Mustonen J
PLoS ONE, 2012-04-16;7(4):e35402.
Species: Human
Sample Types: Plasma
Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
PLoS ONE, 2012-02-16;7(2):e32218.
Species: Human
Sample Types: Serum
Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
Am. J. Pathol., 2011-07-21;179(3):1157-70.
Species: Human
Sample Types: Cell Culture Supernates
Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
PLoS ONE, 2011-06-08;6(6):e20541.
Species: Human
Sample Types: Serum
Probiotic Lactobacillus casei Shirota supplementation does not modulate immunity in healthy men with reduced natural killer cell activity.
Authors: Seifert S, Bub A, Franz CM, Watzl B
J. Nutr., 2011-03-23;141(5):978-84.
Species: Human
Sample Types: Cell Culture Supernates
The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.
Authors: Durig J, Duhrsen U, Klein-Hitpass L, Worm J, Hansen JB, Orum H, Wissenbach M
Leukemia, 2011-03-01;25(4):638-47.
Species: Human
Sample Types: Serum
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010-03-25;115(24):5041-52.
Species: Human
Sample Types: Cell Culture Supernates
Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
Authors: Hergenroeder GW, Moore AN, McCoy JP
J Neuroinflammation, 2010-03-11;7(0):19.
Species: Human
Sample Types: Serum

Clinical efficacy and immune regulation with peanut oral immunotherapy.
Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
Species: Human
Sample Types: Cell Culture Supernates

Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Authors: Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
J. Immunol., 2009-05-15;182(10):6460-9.
Species: Human
Sample Types: Cell Culture Supernates

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
Authors: O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE
Proc. Natl. Acad. Sci. U.S.A., 2009-03-30;106(15):6099-104.
Species: Human
Sample Types: Cell Culture Supernates

Cigarette smoke facilitates allergen penetration across respiratory epithelium.
Authors: Gangl K, Reininger R, Bernhard D, Campana R, Pree I, Reisinger J, Kneidinger M, Kundi M, Dolznig H, Thurnher D, Valent P, Chen KW, Vrtala S, Spitzauer S, Valenta R, Niederberger V
Allergy, 2008-12-16;64(3):398-405.
Species: Human
Sample Types: Cell Culture Supernates

Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.
Authors: El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, Clouet-Delannoy M, Lombardelli L, Jabrane-Ferrat N, Rukavina D, Bensussan A, Piccinni MP, Le Bouteiller P, Tabiasco J
J. Immunol., 2008-09-01;181(0):3009-17.
Species: Human
Sample Types: Cell Culture Supernates

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.
Authors: Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, Scott McIvor R, Wagner JE, Blazar BR, Zhou X
Mol. Ther., 2008-01-29;16(3):580-9.
Species: Human
Sample Types: Cell Culture Supernates

A neoadjuvant/adjuvant randomized trial of colorectal cancer patients vaccinated with an anti-idiotypic antibody, 105AD7, mimicking CD55.
Authors: Ullenhag GJ, Spendlove I, Watson NF, Indar AA, Dube M, Robins RA, Maxwell-Armstrong C, Scholefield JH, Durrant LG
Clin. Cancer Res., 2006-11-22;12(24):7389-96.
Species: Human
Sample Types: Cell Culture Supernates

Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.
Authors: Razonable RR, Henault M, Lee LN, Laethem C, Johnston PA, Watson HL, Paya CV
Antimicrob. Agents Chemother., 2005-04-01;49(4):1617-21.
Species: Human
Sample Types: Cell Culture Supernates

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
Authors: Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W
J. Immunol., 2004-10-01;173(7):4433-42.
Species: Human
Sample Types: Cell Culture Supernates

In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004-03-18;104(2):453-61.
Species: Human
Sample Types: Cell Culture Supernates