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Human IL-8/CXCL8 Luminex Performance Assay

Catalog #: LUH208 Datasheet / COA / SDS

Discontinued Product

LUH208 has been discontinued and is replaced by LUHM208.

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Human IL-8/CXCL8 Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IL-8/CXCL8

Interleukin-8 (IL-8), also known as CXCL8, is a chemokine that is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. IL-8 can form homodimers and heterodimers with CXCL4/PF4. Its bioactivity is regulated by proteolytic truncations, citrullination, and the decoy receptor DARC. IL-8 signals through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines. IL-8 also binds to Serpin A1/alpha-1 Antitrypsin which prevents IL-8 interaction with CXCR1.

Long Name
Interleukin 8
Entrez Gene IDs
3576 (Human); 396880 (Porcine); 403850 (Canine); 493836 (Feline)
Alternate Names
3-10C; AMCF-I; C-X-C motif chemokine 8; CXCL8; CXCL8SCYB8; Emoctakin; GCP1; GCP-1TSG-1; IL8; IL-8; interleukin 8; K60; LAI; LECT; LUCT; LYNAP; MDNCF; MDNCFb-ENAP; member 8; MONAP; MONAPGCP1; NAF; NAP1; NAP-1NAP1; NCF; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor; TCF; TSG1

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Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IL-8/CXCL8 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

36 Citations: Showing 1 - 10
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  1. Identification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery.
    Authors: Stoppelkamp S, Veseli K, Stang K, Schlensak C, Wendel H, Walker T
    PLoS ONE, 2015-08-11;10(8):e0135527.
    Species: Human
    Sample Types: Plasma
  2. Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.
    Authors: Chantratita N, Tandhavanant S, Myers N, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle L, Ernst R, Emond M, Wurfel M, Day N, Peacock S, West T
    PLoS ONE, 2013-11-26;8(11):e81617.
    Species: Human
    Sample Types: Plasma
  3. Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer.
    Authors: Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C
    J Immunol, 2013-03-15;190(8):4420-30.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype.
    Authors: Belmonte L, Beutheu Youmba S, Bertiaux-Vandaele N, Antonietti M, Lecleire S, Zalar A, Gourcerol G, Leroi A, Dechelotte P, Coeffier M, Ducrotte P
    PLoS ONE, 2012-08-17;7(8):e42777.
    Species: Human
    Sample Types: Tissue Homogenates
  5. REDD1 protects osteoblast cells from gamma radiation-induced premature senescence.
    Authors: Li XH, Ha CT, Fu D, Xiao M
    PLoS ONE, 2012-05-18;7(5):e36604.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica.
    Authors: Libraty DH, Makela S, Vlk J, Hurme M, Vaheri A, Ennis FA, Mustonen J
    PLoS ONE, 2012-04-16;7(4):e35402.
    Species: Human
    Sample Types: Plasma
  7. Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1.
    Authors: Schaefers MM, Breshears LM, Anderson MJ, Lin YC, Grill AE, Panyam J, Southern PJ, Schlievert PM, Peterson ML
    PLoS ONE, 2012-03-14;7(3):e32813.
    Species: Porcine
    Sample Types: Cell Culture Supernates
  8. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  9. Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.
    Authors: Moyes DL, Murciano C, Runglall M, Islam A, Thavaraj S, Naglik JR
    PLoS ONE, 2011-11-08;6(11):e26580.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
    Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
    PLoS ONE, 2011-06-08;6(6):e20541.
    Species: Human
    Sample Types: Serum
  12. Effect of Lactobacillus paracasei ST11 on a nasal provocation test with grass pollen in allergic rhinitis.
    Authors: Wassenberg J, Nutten S, Audran R, Barbier N, Aubert V, Moulin J, Mercenier A, Spertini F
    Clin. Exp. Allergy, 2011-04-01;41(4):565-73.
    Species: Human
    Sample Types: Nasal Fluid
  13. The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.
    Authors: Durig J, Duhrsen U, Klein-Hitpass L, Worm J, Hansen JB, Orum H, Wissenbach M
    Leukemia, 2011-03-01;25(4):638-47.
    Species: Human
    Sample Types: Serum
  14. Lipid-heparin infusion suppresses the IL-10 response to trauma in subcutaneous adipose tissue in humans.
    Authors: Ikeoka DT, Pachler C, Mader JK, Bock G, Neves AL, Svehlikova E, Feichtner F, Koehler G, Wrighton CJ, Pieber TR, Ellmerer M
    Obesity (Silver Spring), 2010-11-18;19(4):715-21.
    Species: Human
    Sample Types: Complex Sample Type
  15. Potential biomarkers of osteonecrosis in Gaucher disease.
    Authors: Pavlova EV, Deegan PB, Tindall J, McFarlane I, Mehta A, Hughes D, Wraith JE, Cox TM
    Blood Cells Mol. Dis., 2010-11-13;46(1):27-33.
    Species: Human
    Sample Types: Serum
  16. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010-03-25;115(24):5041-52.
    Species: Human
    Sample Types: Cell Culture Supernates
  17. Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer.
    Authors: Haura EB, Tanvetyanon T, Chiappori A, Williams C, Simon G, Antonia S, Gray J, Litschauer S, Tetteh L, Neuger A, Song L, Rawal B, Schell MJ, Bepler G
    J. Clin. Oncol., 2010-02-08;28(8):1387-94.
    Species: Human
    Sample Types: Plasma
  18. Remodeling of skeletal muscle microvasculature in sickle cell trait and alpha-thalassemia.
    Authors: Vincent L, Feasson L, Oyono-Enguelle S, Banimbek V, Denis C, Guarneri C, Aufradet E, Monchanin G, Martin C, Gozal D, Dohbobga M, Wouassi D, Garet M, Thiriet P, Messonnier L
    Am. J. Physiol. Heart Circ. Physiol., 2009-11-13;298(2):H375-84.
    Species: Human
    Sample Types: Plasma
  19. Clinical efficacy and immune regulation with peanut oral immunotherapy.
    Authors: Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW
    J. Allergy Clin. Immunol., 2009-07-03;124(2):292-300, 300..
    Species: Human
    Sample Types: Cell Culture Supernates
  20. Sputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosis.
    Authors: Laguna TA, Wagner BD, Luckey HK, Mann SA, Sagel SD, Regelmann W, Accurso FJ
    Chest, 2009-06-30;136(6):1561-8.
    Species: Human
    Sample Types: Sputum
  21. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis.
    Authors: Dufresne V, Knoop C, Van Muylem A, Malfroot A, Lamotte M, Opdekamp C, Deboeck G, Cassart M, Stallenberg B, Casimir G, Duchateau J, Estenne M
    Am. J. Respir. Crit. Care Med., 2009-04-02;180(2):153-8.
    Species: Human
    Sample Types: Serum
  22. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.
    Authors: O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE
    Proc. Natl. Acad. Sci. U.S.A., 2009-03-30;106(15):6099-104.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
    Authors: Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF
    Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14.
    Species: Human
    Sample Types: BALF
  24. Estradiol increases IL-8 secretion of normal human breast tissue and breast cancer in vivo.
    Authors: Bendrik C, Dabrosin C
    J. Immunol., 2009-01-01;182(1):371-8.
    Species: Human
    Sample Types: Plasma
  25. Cigarette smoke facilitates allergen penetration across respiratory epithelium.
    Authors: Gangl K, Reininger R, Bernhard D, Campana R, Pree I, Reisinger J, Kneidinger M, Kundi M, Dolznig H, Thurnher D, Valent P, Chen KW, Vrtala S, Spitzauer S, Valenta R, Niederberger V
    Allergy, 2008-12-16;64(3):398-405.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.
    Authors: El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, Clouet-Delannoy M, Lombardelli L, Jabrane-Ferrat N, Rukavina D, Bensussan A, Piccinni MP, Le Bouteiller P, Tabiasco J
    J. Immunol., 2008-09-01;181(0):3009-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  27. An evaluation of commercial fluorescent bead-based luminex cytokine assays.
    Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
    PLoS ONE, 2008-07-02;3(7):e2535.
    Species: Human
    Sample Types: Serum
  28. Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients.
    Authors: Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Ward C, Lordan JL
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-01-18;294(3):L592-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Defining cancer cachexia in head and neck squamous cell carcinoma.
    Authors: Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG
    Clin. Cancer Res., 2007-11-15;13(22):6561-7.
    Species: Human
    Sample Types: Serum
  30. Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock.
    Authors: Sunden-Cullberg J, Nystrom T, Lee ML, Mullins GE, Tokics L, Andersson J, Norrby-Teglund A, Treutiger CJ
    Crit. Care Med., 2007-06-01;35(6):1536-42.
    Species: Human
    Sample Types: Serum
  31. Circulating chemokine levels and miscarriage.
    Authors: Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Rhoton-Vlasak A, Luo X, Chegini N
    Am. J. Epidemiol., 2007-05-15;166(3):323-31.
    Species: Human
    Sample Types: Serum
  32. Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease?
    Authors: Naylor EJ, Bakstad D, Biffen M, Thong B, Calverley P, Scott S, Hart CA, Moots RJ, Edwards SW
    Am. J. Respir. Cell Mol. Biol., 2007-03-15;37(2):135-43.
    Species: Human
    Sample Types: Cell Culture Supernates
  33. Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab.
    Authors: Mirkina I, Schweighoffer T, Kricek F
    Immunol. Lett., 2007-03-01;109(2):120-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  34. Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers.
    Authors: Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S
    J. Allergy Clin. Immunol., 2006-04-27;117(6):1396-403.
    Species: Human
    Sample Types: Saliva
  35. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2.
    Authors: Razonable RR, Henault M, Lee LN, Laethem C, Johnston PA, Watson HL, Paya CV
    Antimicrob. Agents Chemother., 2005-04-01;49(4):1617-21.
    Species: Human
    Sample Types: Cell Culture Supernates
  36. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers.
    Authors: Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP
    Cytometry B Clin Cytom, 2004-09-01;61(1):35-9.
    Species: Human
    Sample Types: Serum

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