Human KLF6 Antibody

Catalog #: AF3499
1 Citation Datasheet / COA / SDS

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AF3499
AF3499-SP

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Product Details

Citations (1)

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Reviews

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human KLF6 Antibody Summary

Species Reactivity

Human

Specificity

Detects human KLF6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows less than 5% cross‑reactivity with rhKLF4, rhKLF5 and rmKLF15.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human KLF6
Met1-Ser109
Accession # Q99612

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human KLF6

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: KLF6

KLF6 is a ubiquitously expressed nuclear protein belonging to the Kruppel C2H2-type zinc finger transcription factor family. It is a 283 amino acid (aa) protein that contains an N-terminal acidic domain, a Ser/Thr-rich region and three zinc-finger motifs. The acidic region may interact with other transcription factors. The Ser-Thr-rich region likely serves as an activation domain, and the zinc-finger motifs bind DNA. One alternate splice form is known that shows a 55 aa substitution for the C‑terminal 57 amino acids. KLF6 is considered a tumor-suppressor gene. It also promotes iNOS and TGF-beta 1 expression. Human KLF6 shares 94%, 95% and 94% aa sequence identity with rat, mouse and canine KLF6, respectively.

Long Name

Kruppel-Like Factor 6

Entrez Gene IDs

1316 (Human); 23849 (Mouse); 58954 (Rat)

Alternate Names

BCD1; BCD1Zf9; B-cell-derived protein 1; COPEB; COPEBCBA1; core promoter element binding protein; Core promoter element-binding protein; CPBP; CPBPZF9; DKFZp686N0199; EC 2.1.1.43; EC 6.1.1.15; GBF; GC-rich binding factor; GC-rich sites-binding factor GBF; KLF6; Krueppel-like factor 6; Kruppel-like factor 6; Kruppel-like zinc finger protein Zf9; PAC1; Proto-oncogene BCD1; protooncogene B-cell derived 1; ST12; suppression of tumorigenicity 12 (prostate); Suppressor of tumorigenicity 12 protein; Transcription factor Zf9

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Human KLF6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma.
Authors: Donev RM, Gray LC, Sivasankar B, Hughes TR, van den Berg CW, Morgan BP
Cancer Res., 2008-07-15;68(14):5979-87.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation