Human LITAF Alexa Fluor® 350-conjugated Antibody

Catalog #: AF4695U Datasheet / COA / SDS

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AF4695U-100UG

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Human LITAF Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LITAF in Western blots.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human LITAF
Met1-Ala111
Accession # Q99732

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LITAF

LITAF (LPS-induced TNF- alpha factor), initially identified through its interaction with the TNF-alpha promoter, is a transcription factor that contributes to the regulation of several inflammatory cytokines in response to LPS or p53 stimulation. LITAF interacts directly with LPS-induced STAT6(B) in the cytoplasm, this complex then translocates into the nucleus, where it significantly up-regulates the transcription of other inflammatory mediators such as, GRO, IL-1 alpha, TNF-alpha, MCP-2 and IFN-gamma. Phosphorylation of LITAF by p38 alpha via the TLR pathway is also required for nuclear translocation. Mutations in LITAF have been associated with CMT1C
(Charcot‑Marie-Tooth neuropathy type 1C) an autosomal dominant demyelinating form of peripheral neuropathy.

Long Name

Lipopolysaccharide-induced TNF Factor

Entrez Gene IDs

9516 (Human); 56722 (Mouse); 65161 (Rat)

Alternate Names

CMT1C; FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; PIG7MGC116701; SIMPLE; SIMPLEMGC125274; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7