Human LRP-6 APC-conjugated Antibody Summary
Accession # O75581
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of LRP‑6 in MDA‑MB‑231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human LRP-6 APC-conjugated Monoclonal Antibody (Catalog # FAB1505A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs.
Citation for Human LRP-6 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia
Authors: Y Ghaleb, S Elbitar, A Philippi, P El Khoury, Y Azar, M Andrianiri, A Loste, Y Abou-Khali, G Nicolas, M Le Borgne, P Moulin, M Di-Filippo, S Charrière, M Farnier, C Yelnick, V Carreau, J Ferrières, JM Lecerf, A Derksen, G Bernard, MS Gauthier, B Coulombe, D Lütjohann, B Fin, A Boland, R Olaso, JF Deleuze, JP Rabès, C Boileau, M Abifadel, M Varret
Sample Types: Whole Cells
Applications: Flow Cytometry
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