Detects human LRP-6 in direct ELISAs. In direct ELISAs, approximately 5% cross-reactivity
with recombinant mouse (rm) LRP-6 and no cross-reactivity with recombinant
human (rh) LRP-1, -4, -5, rhLRP-6 (intracellular domain), or rhLDL R is
Monoclonal Mouse IgG2A Clone # 255302
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human LRP-6 Ala20-Pro1368 Accession # O75581
Supplied in a saline solution containing BSA and Sodium Azide.
Detection of LRP‑6 in MDA‑MB‑231 Human Cell Line by Flow Cytometry.
MDA‑MB‑231 human breast cancer cell line was stained with Mouse Anti-Human LRP‑6 PE‑conjugated Monoclonal Antibody (Catalog # FAB1505P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs.
LDL Receptor-related Protein 6
Entrez Gene IDs:
4040 (Human); 16974 (Mouse)
ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP6; LRP-6
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