Human/Mouse HIF-1 alpha/HIF1A PE-conjugated Antibody
Human/Mouse HIF-1 alpha/HIF1A PE-conjugated Antibody Summary
Arg575-Asn826
Accession # Q16665.1
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of HIF‑1 alpha in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line treated with CoCl2was stained with Mouse Anti-Human/Mouse HIF-1a PE-conjugated Monoclonal Antibody (Catalog # IC1935P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: HIF-1 alpha/HIF1A
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha ) is the regulated member of the transcription factor heterodimer HIF-1. HIF-1 binds to hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF-1 alpha.
Product Datasheets
Citations for Human/Mouse HIF-1 alpha/HIF1A PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on gammadelta T�cells
Authors: JH Park, I Kang, HC Kim, Y Lee, SK Lee, HK Lee
Cell Reports, 2022;41(6):111594.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Epithelial-mesenchymal transition and metastatic ability of CD133+ colorectal cancer stem-like cells under hypoxia
Authors: M Okada, K Kawai, H Sonoda, H Shiratori, J Kishikawa, H Nagata, H Nozawa, K Sasaki, M Kaneko, K Murono, S Emoto, Y Iida, H Ishii, Y Yokoyama, H Anzai, K Hasegawa, S Ishihara
Oncol Lett, 2021;21(1):19.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CD74 is a regulator of hematopoietic stem cell maintenance
Authors: S Becker-Her, M Rozenberg, C Hillel-Kar, N Gil-Yarom, MP Kramer, A Barak, L Sever, K David, L Radomir, H Lewinsky, M Levi, G Friedlande, R Bucala, A Peled, I Shachar
PloS Biology, 2021;19(3):e3001121.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
Authors: Y Sun, X Lin, B Liu, Y Zhang, W Li, S Zhang, F He, H Tian, X Zhu, X Liu, J Wu, J Cai, M Li
Science Advances, 2021;7(52):eabj6877.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism
Authors: LS Sellam, R Zappasodi, F Chettibi, D Djennaoui, N Yahi-Ait M, ZC Amir-Tidad, C Touil-Bouk, W Ouahioune, JD Wolchok, T Merghoub, M Bourouba
Arch. Biochem. Biophys., 2020;690(0):108479.
Species: Human
Sample Types: Cells
Applications: Flow Cytometry -
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
Authors: E Khatib-Mas, S Bhattachar, H Massalha, A Biram, K Golan, O Kollet, A Kumari, F Avemaria, E Petrovich-, S Gur-Cohen, T Itkin, I Brandenbur, A Spiegel, Z Shulman, Z Gerhart-Hi, S Itzkovitz, M Gunzer, S Offermanns, R Alon, A Ariel, T Lapidot
Nat Commun, 2020;11(1):3547.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Induction of HIF-1? by HIV-1 Infection in CD4+ T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation
Authors: G Duette, P Pereyra Ge, J Rubione, PS Perez, AL Landay, SM Crowe, Z Liao, KW Witwer, MP Holgado, J Salido, J Geffner, O Sued, CS Palmer, M Ostrowski
MBio, 2018;9(5):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1?-dependent glycolysis
Authors: Y Lu, H Liu, Y Bi, H Yang, Y Li, J Wang, Z Zhang, Y Wang, C Li, A Jia, L Han, Y Hu, Y Zhao, R Wang, G Liu
Cell. Mol. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
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