Human/Mouse p23/PTGES3 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: p23/PTGES3

Prostaglandin E Synthase 3 (also known as Cytosolic prostaglandin E2 synthase, HSP90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, or p23) is a glutathione-dependent enzyme found in the cyclooxygenase-1-mediated PGE2 biosynthetic pathway. This protein is highly conserved in eukaryotes and in humans it is expressed in most tissues other than striated muscle. Through its prostaglandin synthase activity, p23 contributes to the production of prostaglandin E2 and has a role in maintenance of tissue homeostasis. In addition to its catalytic activity in the prostaglandin biosynthesis pathway, p23 serves as a co-chaperone to HSP90 (Heat Shock Protein 90) in various biological functions. The p23/HSP90 complex is required for efficient telomerase assembly in vitro and in vivo. It has also been demonstrated that p23 and HSP90 localize to genomic response elements in a hormone-dependent manner, and may promote disassembly of transcriptional regulatory complexes in response to changes in cellular signaling pathways. p23 protein is up-regulated in several cancers, notably breast cancer.

Product Datasheets

Related Research Areas

• Bioactive Lipids and Receptors
• Eicosanoids and Regulators
• Lipid/Cholesterol Metabolism Enzymes
• Neurotransmitters, Neuroactive Molecules and Associated Enzymes
• Prostanoids and Receptors
• Steroid Hormones and Bioactive Lipids