Home / Bcl-xL / Human/Mouse/Rat Bcl-xL aa 3-14 Antibody

Human/Mouse/Rat Bcl-xL aa 3-14 Antibody

Catalog #: 2300-MC
7 Citations Datasheet / COA / SDS

Discontinued Product

2300-MC has been discontinued.
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Product Details
Citations (7)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat Bcl-xL aa 3-14 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Anti-Bcl-XL is specific for human, mouse and rat species.
Source
Monoclonal Mouse IgG2A Clone # YTH-2H12
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human Bcl-xL
aa 3-14
Formulation
This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1:1000 dilution
Immunohistochemistry
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4°C.

Background: Bcl-xL

The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. Bcl-XL has been shown to promote cell survival through the regulation of mitochondrial homeostasis.

References
  1. Hsu, Y.-T. et al. 1997, Proc. Natl. Acad. Sci. USA 94: 3668-3672.
  2. Hsu, Y.-T. and R.J. Youle. 1997, J. Biol. Chem. 272: 13829-13834.
  3. Neuchushtan, A. et al. 1999, EMBO J. 18: 2330-2341.
Long Name
B Cell Lymphoma/Leukemia x Long Form
Entrez Gene IDs
598 (Human); 12048 (Mouse); 24888 (Rat)
Alternate Names
Apoptosis regulator Bcl-X; bcl2-L-1; BCL2-like 1; bcl-2-like protein 1; BCLXBCL2LBcl-X; BclxL; Bcl-xL; BCL-XL/S; BCLXS; bcl-xS; DKFZp781P2092

Product Datasheets

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COA

Citations for Human/Mouse/Rat Bcl-xL aa 3-14 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways.
    Authors: Chen R, Siao S, Hsu C, Chang C, Chang L, Wu C, Lin P, Wang Y
    PLoS ONE, 2014-06-13;9(6):e99586.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  2. In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia.
    Authors: Schneider P, Costa O, Legrand E
    Leuk. Res., 2009-09-12;34(1):24-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The role of nerve growth factor in hyperosmolar stress induced apoptosis.
    Authors: Chang EJ, Im YS, Kay EP
    J. Cell. Physiol., 2008-07-01;216(1):69-77.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Interactions between important regulatory proteins and human alphaB crystallin.
    Authors: Ghosh JG, Shenoy AK, Clark JI
    Biochemistry, 2007-05-08;46(21):6308-17.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA-Based Protein Pin Array
  5. Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes.
    Authors: Habens F, Lapham AS, Dallman CL, Pickering BM, Michels J, Marcusson EG, Johnson PW, Packham G
    Oncogene, 2006-09-18;26(13):1910-9.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
    Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
    Gut, 2006-07-13;56(2):243-52.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Abundant apoptosis in nutmeg liver of cardiomyopathic hamsters. Apoptotic cell death as a possible mechanism of hepatic remodeling by congestion.
    Authors: Kawase Y, Takemura G, Hayakawa K, Koda M, Maruyama R, Kanoh M, Kunishima A, Arai M, Minatoguchi S, Ohkusa T, Matsuzaki M, Fujiwara T, Fujiwara H
    Pathol. Res. Pract., 2002-01-01;198(4):291-8.
    Species: Hamster
    Sample Types: Tissue Homogenates
    Applications: Western Blot

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