Human/Mouse/Rat SHIP2 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: SHIP2

SHIP2 (SH2 domain-containing inositol 5-phosphatase 2; also inositol polyphosphate phosphatase-like 1) is a member of the phosphatidylinositol/PtdIns 5-phosphatase family of enzymes. It is widely expressed and negatively regulates PI3 kinase pathways by hydrolyzing the 5-phosphate of PtdIns-3,4,5-triphosphate. Human SHIP2 is 1258 amino acids (aa) in length. It contains one SH2 domain (aa 21‑117), a Pro-rich region with an SH3 binding site (aa 935-1105), and a SAM (or sterile alpha -motif) domain that binds ARAP3 (aa 1196‑1258). SHIP2 is phosphorylated in response to growth factor activation on Tyr986, 1162 and 1358, and on Thr958, among other sites. Over aa 1106‑1258, human SHIP2 shares 95% aa identity with mouse SHIP2.

Product Datasheets

Related Research Areas

• Focal Adhesions
• Glucose Homeostasis
• ITIM/ITAM Immunoreceptors and Related Molecules
• Phosphatases and Regulators
• Phosphatases in the Akt Pathway
• Search Kinases and Phosphatases
• Signaling Molecules and Transcriptional Regulators of Tfh Cell Differentiation