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Human/Mouse SOCS-1 Antibody

Catalog #: K0175-3 Datasheet / COA / SDS

Discontinued Product

K0175-3 has been discontinued.
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Human/Mouse SOCS-1 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
This antibody reacts with human and mouse SOCS-1 on Western blotting.
Source
Monoclonal Mouse IgG1 Clone # 4H1
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Recombinant mouse SOCS-1
aa 2-78
Formulation
100 μg IgG in 100 μL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1-10 μg/mL for chemiluminescence detection system
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody solution is stable for one year from the date of purchase when stored at -20 °C.

Background: SOCS-1

The Suppressor of Cytokine Signaling (SOCS) family of proteins acts in a classic negative feedback loop to regulate cytokine signal transduction.  SOCS-1, also designated Janus kinase (JAK) binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24 kDa protein containing an SH2 domain.  SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation.  SOCS-1 is also induced by and inhibits the signaling action of IL-3, IL-4, LIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN- gamma signaling and T cell differentiation.

References
  1. Izzard, L., et al., J. Gen. Virol. 95, 1880-1885 (2014) [WB]
  2. Madonna, S., et al., J. Immunol. 185, 2467-2481 (2010) [WB, IP, IHC]
  3. Haffner, M. C., et al., J. Biol. Chem. 283, 22089-22096 (2008) [IP]
  4. Mostecki, J., et al., J. Biol. Chem. 280, 2596-2605 (2005)
  5. Vuong, B. Q., et al., Mol. Cell Biol. 24, 9092-9101 (2004)
  6. Croker, B. A., et al., Nat. Immunol. 4, 540-545 (2003)
  7. Zhang, J. G., et al., PNAS 98, 13261-13265 (2001)
  8. Chong, M. M. W., et al., Diabetes 50, 2744-2751 (2001)
  9. Flores-Morales, Al., et al., Mol. Endocrinol. 15, 1471-1483 (2001)
  10. Ohya, K., et al., J. Biol. Chem. 272, 27178-27182 (1997)
Long Name
Suppressor Of Cytokine Signaling 1
Entrez Gene IDs
8651 (Human); 12703 (Mouse); 252971 (Rat)
Alternate Names
CIS1; Cish1; JAB; JABTec-interacting protein 3; JAK binding protein; JAK-binding protein; SOCS1; SOCS-1; SOCS-1CIS1; SSI-1; SSI-1CISH1; SSI1cytokine-inducible SH2 protein 1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; suppressor of cytokine signaling 1; TIP3; TIP-3; TIP3Cish1

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