Human NTAL APC-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: NTAL

Non-T cell activation linker (NTAL), also known as LAT2 and Linker for Activation of B cells (LAB), is a 26-28 kDa, 243 amino acid (aa) type III transmembrane (TM) adaptor protein involved in immunoreceptor signaling. NTAL belongs to the TRAP family of adaptors and is expressed in lipid raft microdomains of B cells, mast cells, neutrophils, monocytes, dendritic cells, activated T cells and NK cells. Rapid tyrosine phosphorylation of NTAL occurs upon BCR aggregation in B cells, Fc epsilon RI aggregation and Kit activation in mast cells, Fc gamma RI aggregation in monocytes, and Dectin-2 ligation on dendritric cells. Phosphorylated NTAL recruits signaling molecules such as Grb2, Gab1, and c-Cbl into receptor-signaling complexes. As a consequence, dendritic cells secrete IL-12, NK cells secrete IFN-gamma, B cells demonstrate an ability to present antigen, and mast cells show enhanced survival. Defects in the NTAL gene may cause Williams-Beuren syndrome, a rare genetic disorder characterized by mild mental retardation, and abnormalities in the cardiovascular and musculo-skeletal systems. One splice variant is known that shows a deletion of aa 112-243. Full-length human NTAL (aa 1-243) shares 49% aa sequence identity with aa 112-243 mouse NTAL.

Product Datasheets

Related Research Areas

• Adaptor Proteins
• Adaptor Proteins in the Akt Pathway