Human NTAL APC-conjugated Antibody

IC4066A has been discontinued. View all NTAL products.
Datasheet / CoA / SDS
Product Details
  • Species Reactivity
  • Specificity
    Detects human NTAL in direct ELISAs and Western blots.
  • Source
    Monoclonal Mouse IgG2B Clone # 440005
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    E. coli-derived recombinant human NTAL
    Accession # Q9GZY6
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
Product Datasheets

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  • Intracellular Staining by Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Intracellular Staining by Flow Cytometry
Detection of NTAL in THP‑1 Human Cell Line by Flow Cytometry. THP‑1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human NTAL APC‑conjugated Monoclonal Antibody (Catalog # IC4066A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). Cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: NTAL

Non-T cell activation linker (NTAL), also known as LAT2 and Linker for Activation of B cells (LAB), is a 26-28 kDa, 243 amino acid (aa) type III transmembrane (TM) adaptor protein involved in immunoreceptor signaling. NTAL belongs to the TRAP family of adaptors and is expressed in lipid raft microdomains of B cells, mast cells, neutrophils, monocytes, dendritic cells, activated T cells and NK cells. Rapid tyrosine phosphorylation of NTAL occurs upon BCR aggregation in B cells, Fc epsilon RI aggregation and Kit activation in mast cells, Fc gamma RI aggregation in monocytes, and Dectin-2 ligation on dendritric cells. Phosphorylated NTAL recruits signaling molecules such as Grb2, Gab1, and c-Cbl into receptor-signaling complexes. As a consequence, dendritic cells secrete IL-12, NK cells secrete IFN-gamma, B cells demonstrate an ability to present antigen, and mast cells show enhanced survival. Defects in the NTAL gene may cause Williams-Beuren syndrome, a rare genetic disorder characterized by mild mental retardation, and abnormalities in the cardiovascular and musculo-skeletal systems. One splice variant is known that shows a deletion of aa 112-243. Full-length human NTAL (aa 1-243) shares 49% aa sequence identity with aa 112-243 mouse NTAL.

  • Long Name:
    Non-T Cell Activation Linker
  • Entrez Gene IDs:
    7462 (Human); 56743 (Mouse); 317676 (Rat)
  • Alternate Names:
    LAB; LABWilliams-Beuren syndrome chromosomal region 15 protein; Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T-cells family member 2; Membrane-associated adapter molecule; Non-T-cell activation linker; NTAL; NTALWilliams-Beuren syndrome chromosomal region 5 protein; WBS15; WBSCR15; WBSCR5; WBSCR5HSPC046; Williams-Beuren syndrome chromosome region 5; WSCR5
Related Research Areas


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