Human PI 3-Kinase p85 beta (NP_005018.2) VersaClone cDNA

R&D Systems | Catalog # RDC3575

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Key Product Details

Species

Human

Accession Number

NP_005018.2

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PI 3-Kinase p85 beta

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 beta). p85 beta is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 beta is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Long Name

Phosphatidylinositol-3-kinase 85 kDa Regulatory Subunit beta

Alternate Names

p85-beta, PI 3Kinase p85 beta, PIK3R2

Entrez Gene IDs

5296 (Human); 18709 (Mouse); 29741 (Rat)

Gene Symbol

PIK3R2

UniProt

NP_005018.2

Additional PI 3-Kinase p85 beta Products

Product Documents for Human PI 3-Kinase p85 beta (NP_005018.2) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human PI 3-Kinase p85 beta (NP_005018.2) VersaClone cDNA

For research use only

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