Human PTGER1 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: PTGER1

PTGER1 is a one of four EP₁ receptors for PGE2 which is mediated by G(q) proteins.  PTGER1 may play a role as an important modulator of renal functions.  It has also been detected in mast cells, pulmonary veins, keratinocytes, myometrium and colon smooth muscle. EP₁ expression has also frequently been seen in human breast cancers.  Nuclear expression of EP₁ correlates with good prognosis markers like node negative status and PR expression. Animal model studies have implicated EP₁ in various physiological and pathological responses however expression in humans appears to be more limited. EP₁ receptor antagonists have been studied clinically primarily to treat hyperalgesia.

Product Datasheets

Related Research Areas

• Bioactive Lipid G Protein-Coupled Receptors
• Bioactive Lipids and Receptors
• Eicosanoids and Regulators
• G Protein-Coupled Receptors in Immune Responses
• Prostanoids and Receptors
• Steroid Hormones and Bioactive Lipids